| Question |
Answer |
| Beta Agonists |
Airway obstruction in asthmas and COPD |
| Albuterol, Levalbuterol, Metaproterenol |
Acute airflow obstruction |
| Salmeterol, Formoterol, Arformetorol |
Maintenance bronchodilation, control bronchospasm |
| Racemic Epi |
Reduce AW swelling after extubation or epiglottitis, croup, or control AW bleeding |
| What is the mode of action of adrenergic drugs? |
stimulation of Beta 2 receptors located in bronchial smooth muscle` |
| What are the effects of Alpha receptor stimulation? |
Vasoconstriction in upper AW, decongestion |
| What are the effects of Beta 1 receptor stimulation? |
Increased heart conductivity, heart rate, and contractile force |
| What are the effects of Beta 2 receptor stimulation? |
Relaxation of bronchial smooth muscle, mucociliary clearance, some inhibition of inflammation |
| What are the side effects of Beta adrenergic bronchodilators? |
Tachycardia, nervousness, tremors, nausea |
| Terbutaline |
stop contractions in premature labor |
| What is responsible for the breakdown of Beta agonist? |
COMT |
| What breaks down C3'5'AMP to 5 AMP? |
Phosphodiesterase |
| How does bronchodilation occur? |
Attachment to Beta 2 receptors - Gs protein - adenylyl cyclase - C3'5'AMP |
HHS Shrek
