Drug profiles

Description:	Bumex, thiamine morphine, phenergan, valium
Category:	Paramedic/EMT
Created by:	klindley on 2009-06-30

Question	Answer
BUMETANIDE GENERIC NAME	BUMETANIDE
BUMETANIDE BRAND NAME	Bumex
BUMETANIDE CLASS	Loop diuretic
BUMETANIDE MECHANISM OF ACTION	Inhibits electrolyte reabsorption.
BUMETANIDE INDICATIONS	Pulmonary edema, CHF
BUMETANIDE CONTRAINDICATIONS	Hypersensitivity, Anuria, Electrolyte deficiencies, Hepatic coma.
BUMETANIDE ADVERSE REACTIONS	Dizziness , headache, Hypotension, ECG changes, N/V, ringing in the ears.
BUMETANIDE INCOMPATABILITIES/DRUG INTERACTIONS	Lithium toxicity may be potentiated by electrolyte depletion. Potentiates effects of various antihypertensive drugs
BUMETANIDE DOSE/ROUTE Adult	0.5 to 1.0 mg IV slowly over 1 to 2 minutes, or IM
BUMETANIDE ONSET OF ACTION	IV Immediate
BUMETANIDE PEAK EFFECTS	IV 15-30 minutes
BUMETANIDE DURATION OF ACTION	2-4 hours
BUMETANIDE AZ DRUG BOX SUPPLY RANGE	4mg
Promethazine GENERIC NAME	Promethazine
Promethazine BRAND NAME	Phenergan,
Promethazine CLASS	Antiemetics, antihistamine, sedative/hypnotics
Promethazine MECHANISM OF ACTION	Decreases N/V by antagonizing H1 receptors
Promethazine INDICATIONS	Treatment and prevention of N/V
Promethazine CONTRAINDICATIONS	Narrow-angle glaucoma, children less then 2yr.
Promethazine ADVERSE REACTIONS	Confusion, disorientation, sedation, dizziness, nervousness. Blurred vision, diplopia.
Promethazine INCOMPATABILITIES/DRUG INTERACTIONS	Potentiates other CNS depressants, Potentiates other drugs possessing anticholinergic properties.
Promethazine DOSE/ROUTE Adult antihistamine IV	25mg, may repeat in 2hr.
Promethazine DOSE/ROUTE Adult antiemetic IV	25mg Q4hr PRN.
Promethazine DOSE/ROUTE Peds antihistamine IV	Not recommended
Promethazine DOSE/ROUTE Peds antiemetic IV	0.25-0.5 mg/kg q 4-6 hours
Promethazine ONSET OF ACTION	IV 5 minutes
Promethazine PEAK EFFECTS	Unknown
Promethazine DURATION OF ACTION	12 hours
Promethazine AZ DRUG BOX SUPPLY RANGE	Not carried
Thiamine GENERIC NAME	None
Thiamine BRAND NAME	Thiamine
Thiamine CLASS	Vitamin B1
Thiamine MECHANISM OF ACTION	Combines with ATP to form thiamine pyrophosphate coenzyme, a necessary component for carbohydrate metabolism. Thiamine INDICATIONS
Thiamine CONTRAINDICATIONS	None
Thiamine ADVERSE REACTIONS	Hypotension from to rapid of an injection or to high of a dose, diaphoresis, N/V.
Thiamine INCOMPATABILITIES/DRUG INTERACTIONS	Give thiamine before glucose under all circumstances.
Thiamine DOSE/ROUTE Adult	100mg slow IV, or IM
Thiamine DOSE/ROUTE Pediatric	25mg slow IV, or IM
Thiamine ONSET OF ACTION	Rapid
Thiamine PEAK EFFECTS	Variable
Thiamine DURATION OF ACTION	Variable
Thiamine AZ DRUG BOX SUPPLY RANGE	100mg
Diazepam GENERIC NAME	Diazepam
Diazepam BRAND NAME	Valium
Diazepam CLASS	Benzodiazepine, sedative hypnotic, anticonvulsant
Diazepam MECHANISM OF ACTION	Potentiates effects of inhibitory neurotransmitters. Raises seizure threshold. Induces amnesia and sedation.
Diazepam INDICATIONS	anxiety, alcohol withdrawal, muscle relaxant, seizure activity, agitation. Analgesia for medical procedures.
Diazepam CONTRAINDICATIONS	glaucoma, coma, shock, substance abuse, head injury
Diazepam ADVERSE REACTIONS	Respiratory depression, hypotension. Drowsiness, nausea, confusion,
Diazepam INCOMPATABILITIES/DRUG INTERACTIONS	Incompatible with most drugs, fluids.
Diazepam DOSE/ROUTE Adult, seizure activity	5-10mg IV q 10-15 minutes prn. Max dose 30mg.
Diazepam DOSE/ROUTE Adult, cardioversion sedation	5-15mg IV over 5-10 minutes prior to cardioversion.
Diazepam DOSE/ROUTE Pediatric, seizure activity	0.2-0.5mg slowly q 2-5 minutes up to 5mg. max dose 10mg/kg.
Diazepam DOSE/ROUTE Pediatric, rectally	0.5 mg/kg via 2’’ rectal catheter and flush with 2-3ml of air after administration.
Diazepam ONSET OF ACTION	5 minutes
Diazepam PEAK EFFECTS	minutes
Diazepam DURATION OF ACTION	50 minutes
Diazepam AZ DRUG BOX SUPPLY RANGE	20mg. Rectal 20mg (optional)
Morphine GENERIC NAME	Morphine Sulfate
Morphine BRAND NAME	Astramorph/pf
Morphine CLASS	Opioid analgesic (schedule II narcotic)
Morphine MECHANISM OF ACTION	Alleviates pain through CNS action, Suppresses fear and anxiety centers in brain
Morphine INDICATIONS	CHF, pulmonary edema, chest pain associated with acute MI, analgesia for pain
Morphine CONTRAINDICATIONS	depressed respiratory drive, hypotension, undiagnosed abdominal pain, decreased LOC, Shock,
Morphine ADVERSE REACTIONS	Respiratory depression, hypotension, decreased LOC, N/V, Bradycardia, tachycardia, syncope
Morphine INCOMPATABILITIES/DRUG INTERACTIONS	CNS depressant may potentiate effects of morphine. MAOIs may cause paradoxical excitation.
Morphine DOSE/ROUTE Adult Initial dose	2-4 mg IV.
Morphine DOSE/ROUTE Repeat dose	2-8 mg at 5-15 minute intervals.
Morphine DOSE/ROUTE Pediatric	.1-.2 mg/kg per dose via IV. IO. IM, or SC; Maximum dose of 5mg.
Morphine ONSET OF ACTION	Immediate
Morphine PEAK EFFECTS	20 minutes
Morphine DURATION OF ACTION	7 hours
Morphine AZ DRUG BOX SUPPLY RANGE	20mg