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OB Preterm & PROM
Preterm Labor and Premature Rupture of Membranes
| Question | Answer |
|---|---|
| preterm labor | defined as regular ctx’s AND cervical dilation before 37-wks |
| PROM | rupture of membranes before onset of labor. if before 37-wks is referred to as PPROM (preterm premature rupture of membranes) |
| Leading causes of preterm deliveries | Preterm labor (PTL) and preterm premature rupture of membranes (PPROM) are the main leading causes of preterm deliveries |
| Leading cause of developmental disability in children | Pre-term delivery. including cerebral palsy and mental retardation. important cause of blindness and chronic lung problems |
| National Average of pre-term births | 12.1%. AA higher at 17% |
| Potential Risk factors for Preterm labors | Smoking, AA, maternal age: youngest and oldest, Stressful social factors (poverty, poor housing, crime). Underlying biological mechanisms poorly understood. |
| Biggest predictor for having a preterm delivery is | having previous preterm delivery |
| Screening Predictors of the risk of PTD | Cervical length measured by US (may be predictive), Biochemical meausre: fetal fibronectin (if FFN is negative, it is most likely you will not have a PTD, Negative predictive value is high. Positive Predictive value is less useful, on the fence) |
| Cervical Length as a Predictor of PTD | Reliable and reproducible. Cervical shortening associated with preterm delivery. However, very variable predictive value. Not recommended alone |
| Treatment with Progesterone in pregnant women with previous PTD showed | decreases in PTD, less fetal problems. So far, studies are in high risk women |
| Role of tocolytic agents in PTL | Efforts to treat ♀ with tocolytic agents for premature labor after it has been diagnosed have had minimal success and have NOT resulted in improved perinatal outcomes. May prolong gestation 2-7 days (give steroids to improve lung maturity) |
| Tocolytic agent that has an AE of cardiac arrhythmias | Beta-mimetic |
| Tocolytic agent that has an AE of pulmonary edema? | Magnesium Sulfate (most widely used) |
| Tocolytic agent that has an AE of maternal hypotension | Calcium Channel Blockers (stops contractions. Data is good) |
| Antenatal steroids Benefits | Benefits - significant reduction in the risk of respiratory distress syndrome (RDS), mortality and intraventricular hemorrhage (IVH) |
| Antenatal Steroids: who should get them? | Should be given to all women at risk for preterm delivery between 24-34 wks |
| management of PTL: what does NOT work? | Bedrest, hydration, pelvic rest, antibiotics |
| PPROM | Preterm Premature Rupture of Membranes. Associated with PTD. 85% will enter PTL within 1 week. Intraamniotic infxn clinically evident in 13-60%. Placenta abruption occurs in 4-12%. Risk for pulmonary hypoplasia (if ROM<26weeks) |
| Development of lungs | is facilitated by swallowing, so if a women have PPROM, then the baby has nothing to swallow |
| PPROM Risk Factors | Intraamniotic infxn, prior hx, low SES, teenager, smoker, hx of STD, hx of cervical cerclage, uterine overdistention |
| Diagnosis/Evaluation of PPROM | Hx, Sterile Speculum Exam (pooling, ferning, nitrazine positive pH>6--will be false positive if recent sex of bleeding), vaginal/cervical cultures. NO digital exam, odor, tender belly, fever, tachycardia (infxn signs) |
| No steroids are given in PPROM if mom is less than __ weeks along | <24 weeks. |
| PPROM Management | Monitor CBC and vitals (temp), Daily fetal testing, Abx (7-day course) |