Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
rheumathoid Arth
chapter 94 Dipiro's drugs
| Question | Answer | |
|---|---|---|
| methotrexate (rheumatrex) | oral or IM: 7.5-15 mg q WEEK | CI in nursing preg liver or less than |
| leflunomide (arava) | oral 100 mg dialy for 3 days then 10-20 mg daily or 10-20 mg daily without loading dose | inhibit purine CI in liver disease contra nursing or pregers |
| hydroxychloroquine (plaquenil | oral 200-300 mg bid, after 1-2 months may decrease to 200 mg bid or daily | for pregers eye exam q 6 months |
| sulfasalazine (azulfadine) | 500 mg bid, then increase to 1 gram bid max | prodrug not for sulfa allergy, ADR limit use |
| etanercept (enbrel) | 50 mg SC wekkly | TNF inhibitors2 TNF receptors linked to an Fc fragment of human IgG1 |
| inflixidmab (remicade) | 3 mg/kg IV at 0, 2, 6 weeks then q 8 weeks | TNF inhibitorchimeric anti-TNF antibody fused to a human constant region IgG1 |
| adalimumab (Humira) | 40 mg SC q 2 weeks | TNF inhibitorHuman IgG1 antibody to TNF |
| anakinra (Kineret) | 100 mg SC daily | interleukin 1 inhibitor IL-1 receptor antagonist not to be used with TNF blocking agents |
| rituximab (Rituxan) | 1000 mg twice 2 weeks apart | depletes peripheral b cells |
| abatacept (Orencia | < 60 kg 500 mg60-100 kg 750 mg>100 kg 1000 mg | Prevent t-cell activationinhibits interaction between the anti presenting cells and T cells preventing T cells from activation to promote inflammatory process |
| cyclosporine | oral 2.5 mg/kg/day | reduces production of cytokines involved in T cell activation |
| azathioprine (imuran) | 50-100 mg daily | watch in renal dys fxn |
Created by:
lainylaina