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Pharm Derm
Pharmacology for Dermatology
| Question | Answer |
|---|---|
| anerobe involved in acne | P. acnes bacteria |
| oral abx and oral contraceptives are used in | moderate to severe inflammatory acne |
| Severe of refractory acne can be treated with | isotretinoin |
| Most important cause of treatment failure | lack of compliance |
| ___ are preferred for oily skin | gels. Creams and lotions for dry skin |
| How long should oral abx be given for? | 6 months, and may take 6-8 weeks for visible effect |
| ___ requires gradual exposure each day (15min to 2 hours to overnight) | benzoyl peroxide. burns. Remove with soap and water |
| ___ bleaches hairl, towels, carpet, etc | benzoyl peroxide. DC if no improvement after 6 weeks |
| Salicylic acid should be avoided in which populations? | Diabetes, poor circulation, infants, pregnancy (category C) |
| Salicylic acid strength for acne | <6% (destructive to tissues greater than 6%) |
| ________Produces a reversible, dark brown scale on darker-skin (resorcinol) | Sulfur/Resorcinol (clearasil) |
| _______Decreases the adhesiveness of follicular epithelial cells, stimulates mitosis and turnover of epithelial cells causing extrusion of the comedones | Tretinoin/retin-A. Use at night time b/c UV light destroys it. Gets worse before it gets better |
| Starting dose of Tretinoin/Retin-A | .25%, then gradually increase |
| ________ should not be used in combination with benzoyl peroxide | tretinoin. counteracts |
| ___ is often tolerated better than Retin-A | Adapalene |
| ____ is second-line retinoid; stronger and more AEs | Tazarotene |
| Which acne treatment is pregnancy category X | Tazarotene |
| Which Rx inhibit P. acnes? | Clindamycin>Erythromycin |
| ___ can cause hypopigmentation/vitiligo in people with darker complexion | Azelaic Acid. |
| ___ is an acne med that may worsen asthma, allergy and herpes labialis | Azelaic Acid |
| Long term treatment of Tetracycline requires | monitoring of LFTs and CBC. |
| Who should not be treated with tetracycline? | children under 9 for teeth purposes. |
| ____ is a associated with the rare AE of bulging fontanelles,immune hypersensitivity, lupus and pseudocerebri, | Minocycline. Better tolerated than tetracycline. Higher doses do not confer greater efficacy; tx for 12 weeks. LFTs, renal and CBC monthly for long term therapy |
| Which oral abx should you not take take calcium, iron, magnesium or aluminum antacids or supplements within 4 hours | Doxycycline |
| ______ is available only under restricted distribution: iPLEDGE | Isotrentinoin. Pregnancy category X and tons of AEs. Males and females must document 2 forms of contraception 1 month before and 1 month after tx |
| Dosage of Isotrentinoin is based on | weight in kg. |
| How many negative pregnancy tests are required prior to beginning Isotrentinoin? | 2 |
| AE's of Isotrentinoin | Dry skin and mucous membranes, Lip inflammation (90%), hypertriglyceridemia, myalgia, anemia, conjunctivitis, skin irritation. EVERYTHING IS DRY! |
| Main cause of nongenital warts | HPV |
| Cryotherapy notes | Aggressive therapy (2 minutes, double freeze) is more effective than less aggressive (15 seconds, single freeze) but causes more pain and blistering |
| What percentage rate of Salicylic acid is used for nongenital warts | >6% |
| Tx options for nongenital warts | cryotherapy and salicylic acid |
| Which medication is recommended for small localized lesions caused by bacteria? ex: impetigo or folliculitis | Bactroban (mupirocin) |