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Diabetic Drugs MOA

oral medications

QuestionAnswer
Nateglinide Stimulate insulin secretion.Nonsulfonylurea secretagogues (Glinides)(Starlix)
Repaglinide Stimulate insulin secretion.Nonsulfonylurea secretagogues (Glinides)(Prandin)
Acetohexamide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.1st Sulfonylureas (Dymelor)
Chlorpropamide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.1st Sulfonylureas (Diabinese)
Tolazamide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.1st Sulfonylureas (Tolinase)
Tolbutamide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.1st Sulfonylureas (Orinase)
Glimepiride Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.2nd Sulfonylureas (Amaryl)
Glipizide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.2nd Sulfonylureas (Glucotrol)
Glyburide Stimulate insulin secretion. May decrease hepatic glucose output and enhance peripheral glucose utilization.2nd Sulfonylureas (Diabeta, Micronase)
Exenatide Stimulates insulin secretion, delays gastric emptying, reduces postprandial glucagon levels, improved satietyGlucagon-like peptide -1 receptor agonists/Incretin Mimetic (Byetta)
Sitagliptin Stimulates insulin secretion and reduces postprandial glucagon levelsDPP-4 Inhibitors (Januvia)
Pramlintide Stimulates insulin secretion, delays gastric emptying, reduces postprandial glucagon levels, improved satietyAmylin mimetic (Symlin)
Metformin ↓ Hepatic glucose output;↑ Peripheral glucose uptakeBiguanides (Glucophage)
Pioglitazone Enhance insulin action in periphery; increase glucose utilization by muscle and fat tissue; decrease hepatic glucose outputThiazolidinediones (Actos)
Rosiglitazone Enhance insulin action in periphery; increase glucose utilization by muscle and fat tissue; decrease hepatic glucose outputThiazolidinediones (Avandia)
Miglitol Slow absorption of complex carbohydrates.α-Glucosidase inhibitors (Glyset)
Acarbose Slow absorption of complex carbohydrates.α-Glucosidase inhibitors (Precose)
Created by: lainylaina
 

 



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