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seizures lynch
therapeutics
| Question | Answer |
|---|---|
| felbamate | inhibitor so increase phenytoin, valproic acid, and phenobarbital |
| oxcarbazepepine | inhibitor of 2C9 increases concentrations of phenytoin |
| valproic acid | inhibitor, increase phenobarb,10,11 carbamazepine epoxide, and increase lamotrigine (interactions through Glucoronidation and VPA wins, decrease the lamtrigine dose by half) |
| topiramate | increases phenytoin by inhibiting CYP2C19 increase clearnace of VPA and increase ethinyl estradiol |