| Question |
Answer |
| GENERIC NAME |
None |
| BRAND NAME |
Atropine |
| CLASS |
Anticholinergic agent |
| MECHANISM OF ACTION |
Parasympatholytic; Inhibits action of acetylcholine at postganglionic parasympathetic neuroeffector sites. Increases HR in life threatening bradyarrhythmias. |
| INDICATIONS |
Hemodynamically unstable Bradycardia, Asystole, Bradycardic (<60 beats a minute) PEA, Organophosphate poisoning, bronchospastic pulmonary disorders. |
| CONTRAINDICATIONS |
Tachycardia, Hypersensitivity, unstable cardiovascular status in acute hemorrhage and myocardial ischemia, narrow-angle glaucoma. |
| ADVERSE REACTIONS |
Headache, dizziness, Palpitations, N/V, Tachycardia, arrhythmias, anticholinergic effects (blurred vision, dry mouth, urinary retention), paradoxical Bradycardia when pushed slowly or at low doses, flushed, hot, dry skin. |
| NOTES ON ADMINISTRATION |
Pregnancy category C, Moderate doses may cause pupil dilation. |
| INCOMPATABILITIES/DRUG INTERACTIONS |
Potential adverse effects when administered with digoxin, cholinergics, physostigmine. Effects enhanced by antihistamines, procainamide, quinidine, antipsychotics, benzodiazepines, and antidepressants. |
| DOSE/ROUTE; Adult,Asystole and Bradycardic PEA |
1mg IV/IO push may repeat every 3-5 minutes up to 3 doses. |
| DOSE/ROUTE, ADULT, Unstable Bradycardia |
0.5 mg IV/IO every 3-5 minutes not to exceed 3mg total. |
| DOSE/ROUTE, ADULT, Organophosphate Poisoning |
Extremely large doses (2-4mg or higher) |
| DOSE/ROUTE,PEDEATRIC |
0.02 mg/kg IV/IO push. May double for second dose. Minimum single dose is 0.1 mg. |
| DOSE/ROUTEChild |
0.02 mg/kg IV/IO push. May double for second dose. Maximum single dose in child is 0.5mg. Max total dose is 1mg |
| DOSE, Adolescent single dose |
1mg and total dose 2mg. |
| ONSET OF ACTION |
Immediate |
| PEAK EFFECTS |
Rapid to 1-2 minutes |
| DURATION OF ACTION |
Duration 2-6 hours |
| AZ DRUG BOX SUPPLY RANGE |
(4)prefilled 1mg syringes. Total 4mg (1)8mg Multidose vial. |
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