| Question |
Answer |
| what are the non-inflammatory E coli illnesses? (do not see fecal WBCs) |
Enterotoxigenic (ETEC), Enteropathogenic (EPEC), Enteroaggregative (EAggEC) |
| E coli that cause invasive disease |
Enteroinvasive (EIEC), Enterohemorrhagic (EHEC) |
| ETEC characteristics |
**traveler's diarrhea** abrupt onset watery diarrhea, lasts 24 hours long after fluids replaced, Toxins |
| ETEC toxins |
Heat labile toxin- A-B toxin like cholera......Heat stable toxin- stimulates cGMP and secretes Cl- into the lumen ( osmotic diarrhea) |
| EPEC characteristics (no toxin) |
**most common in children**attach to ep cells and disrupt microvilli.. unique type III secretory system |
| EPEC attachment |
Tir receptors put in ep cell and intimin put on bacterial cell....causes actin rearrangement a pedestal emerges from the cell |
| EAggEC characteristics |
*** persistent diarrhea*** 3 stages (1. adhere to mucous, 2. enhance mucous formation, 3. cytotoxin damages cell) |
| Treatment for inflammatory E. coli infections |
replace fluids and antibiotics may help shorten duration |
| EIEC characteristics |
similar pathogenesis to Shigella (shiga toxin kills cells, lives intracellularly) watery diarrhea |
| EHEC characteristics |
***most infect large bowel***, kidney damage from shiga toxin, Hemorrhagic colitis or hemolytic uremic syndrome |
| Hemolytic uremic syndrome is.... |
triad of symptoms...1. renal failure 2. thrombocytopenia 3. microangiopathic hemolytic anemia |
| diagnosis and treatment of invasive E. coli |
EHEC----0157:H7--inability to ferment sucrose----avoid antibioitics (may release more toxin) |
| listeria monocytogenes seen in..... |
maternal infection during pregnancy |
Cardio Block2anatomy
