| Question |
Answer |
| Folic acid analog that inhibits dihydrofolate reductase |
Methotrexate |
| Pyrimidine analog that inhibits thymidylate synthase |
5-fluorouracil |
| Inhibitor of de novo purine synthesis |
6-mercaptopurine |
| Inhibits DNA polymerase |
cytarabine |
| Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. Notable side effect of hemorrhagic cystitis |
Cyclophosphamide, ifosfamide |
| Alkylating agent capable of crossing blood brain barrier |
Nitrosureas (carmustine, lomustine) |
| Similar to alkylating agent, notable toxicities include nephrotoxicity and acoustic nerve damage |
Cisplatin, carboplatin |
| Alkylating agent used to treat CML |
Busulfan |
| Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) |
Doxorubicin (Adriamycin), daunorubicin |
| Used to treat childhood tumors (Wilm's tumor, rhabdomyosarcoma, and Ewing's sarcoma) |
Dactinomycin (Actinomycin D; Children ACT out)
|
| Free radical generator which can cause life threatening pulmonary fibrosis |
Bleomycin |
| Topoisomerase II inhibitor |
Etoposide |
| Steroid that triggers apoptosis |
Prednisone |
| Estrogen receptor antagonist |
Tamoxifen
|
| Monoclonal antibody against HER-2 |
Trastuzumab |
| Philadelphia chromosome bcr-abl tyrosine kinase inhibitor |
Imatinib (Gleevec) |
| Binds tubulin blocking polymerization of microtubules and mitotic spindle formation |
Vincristine, vinblastine |
| Binds tubulin hyperstabalizing microtubules and blocking mitotic spindle formation |
Paclitaxel |
| Toxicity includes Cushing-like symptoms |
Prednisone |
| Used for "metastatic" breast cancer |
Trastuzumab |
| Increased risk of endometrial carcinoma |
Tamoxifen |
| Do not use with allopurinol |
6-mercaptopurine (activated by xanthine oxidase; allopurinol is a xanthine oxidase inhibitor used to treat gout) |
| CNS toxicity |
Nitrosureas (carmustine, lomustine |
| Reversible myelosuppression with leucovorin rescue |
Methotrexate |
| Neurotoxic (areflexia, peripheral neuritis) paralytic ileus |
Vincristine (Vinblastine is notable for bone marrow suppression) |
| Antineoplastic used for therapeutic abortion |
Methotrexate |
| Androgen receptor antagonist |
Flutamide |
| Recombinantly produced cytokine used to treat hairy cell leukemia |
Interferon alpha |
| GnRH agonist used for the treatment of metastatic prostate carcinoma |
Leuprolide, Goserelin, Nafarelin |
| Monoclonal antibody used for treatment of low grade non-Hodgkin lymphoma |
Rituximab |
| Aromatase inhibitor used to treat breast cancer |
Anastrozole |
Beef Production
