| Question |
Answer |
| What laboratory evaluation of platelets does the following describe: Utilizes Platelet aggregometer, platelet rich plasma(37degC), and is stirred with a small magnetic bar to allow more light to pass through the suspension? |
Aggregation Studies(principal in determing Primary Hemostasis) |
| Name the lab eval of platelets from the following hints: Congenital or Aquired D/O and assesses In-Vivo platelet function. |
Bleeding Time |
| Can a periphial blood smear be used for aggregation studies of platelets? |
Yes |
| What are the Factors involved in the Intrinsic Pathway Activation? |
XII , XI , IX , VIII |
| What is the Factor involved in the Extrinsic Pathway Activation? |
VII |
| What are the Factors involved in the Common Pathway Activation? |
X , V , II , I |
| Name the Factors in the Fibrinogen group? |
I, V , VIII , XIII |
| Name the Factors in the Prothrombin group? |
II , VII , IX , X |
| Name the Factors in the Contact group? |
XI, XII , HMWK , PK |
| What Factor group is Vitamin K dependent? |
Prothrombin Group |
| Which Factor group is completely consumed in the coagulation process? |
Fibrinogen Group |
| What Factor is consumed in the Prothrombin group during coagulation? |
Factor II |
| What Factor group is not being synthesized during HDN? |
Prothrombin Group |
| Limited Vit K storage and Vit K production is an indicator of what? |
Immature liver |
| What is the treatment for HDN? |
Vit K |
| During FDP test, latex particles in glycerine buffer are coated with __________ to human fibrinogen fragments: Frag ____ and Frag _____. |
Specific Ab, D , E |
| Presence of FDP's in either serum or urine will cause latex particles to _______, yielding _____________ _____________. |
clump, macroscopic agglutination |
| The latex particles provided in the D-Dimer Assay are coated with _______ anti-_______ D-dimer monoclonal bodies. |
mouse, human |
| Test sample containing D-dimer when mixed with latex particle suspension make the particles __________. |
agglutinate |
| Positive D-Dimer assay may be seen in clinical situations where active _________ is occuring such as DIC, DVT, and primary embolism. |
thrombosis |
| Plasmin is formed in the absence of coagulation taking place describes what disorder? |
Primary Fibrinolysis |
| Results from hypofibrinogenemic state induced by the proteolytic cleavage of fibrinogen by excess plasmin, in addition to the catabolic effect of the enzyme factors V and VIII. |
Secondary Fibrinolysis |
| What are the three naturally occuring anti-coagulants? |
Anti-thrombin III,Nat. Occuring Heparin, and Protein C & S (cofactor) |
| Name 3 aquired anti-coagulants? |
Lupus Anticoagulant, Heparin, and Coumarin/warfarin |
| Coumarin/warfarin interferes with the recycling of what vitamin? |
K |
| What test monitors coumarin/warfarin therapy? |
PTT |
| Heparin acts to accelerate the rate of _________ by binding the serine protease, irreversibly inhibiting its activity. |
anti-thrombin III |
| What test is used to monitor heparin therapy? |
aPTT |
| Name the common laboratory screening tests for hemostatic D/O's? |
PLT count, Periphial Smear, PTT, aPTT, TT, Bleeding Time. |
| What anticoagulant should be used in specimen collection? |
sodium citrate |
| PT measures what factors? |
I, II, V, X, VII (prothrombin group, due to the need of vitamin K) |
| PT helps to measure early Vitamin ___ deficiences. |
K |
| Ref. Range for PT is ___ - ____ seconds. |
10 - 13 |
| aPTT evaluates the _______ pathway of coagulation. |
intrinsic |
| The purpose of the aPTT is to screen for _________ in the intrinsic pathway. |
inhibitors |
| The aPTT is clinically significant due to its ability to screen/detect circulating _________. |
Anticoagulants |
| The ref. range for aPTT is ______ - ________ seconds. |
25-35 seconds |
| Mixing studies are a diagnostic evaluation of unexplained prolonged ______ and ______ tests. |
aPTT and PT |
| Mixing studies will only be performed when _________. |
requested by a health care provider. |
| Mixing studies use commercially prepared ________ ___________ __________. |
pooled normal plasma |
| What test evaluates the time required for thrombin to convert fibrinogen to an insoluble fibrin clot? |
TT |
| The normal value time range should be ____ to _____ seconds. |
10 - 15 |
| what buffer is used when quantitatively measuring fibrinogen? |
owren's veronal buffer (pH 7.35) |
| Normal value range for fibrinogen is _______ to ________ mg/dL. |
200-400 |
| What is the test used to screen for platelet dysfunction, testing mainly for primary hemostasis and platelet function. |
BT |
| Name the 3 BT methods? |
Ivy, Duke, and Mielke |
| what is the normal clotting time when performing the ivy testing method? |
0-8 minutes. |
| Bernard Souliers Syndrome will show abnormal _______ and _________ during aggregation studies. |
Thrombin and Ristocetin |
| Glanzmann's thrombasthenia is a deficiency in glycoprotein contents, all aggregation studies will show abnormal except for ________. |
Ristocetin |
| Decreased production of prostacyclin is a key indicator of the secondary condition due to drugs or infx is ________________ |
Thrombotic Thrombocytopenic purpura |
| Acute blood loss, vigorous exercise, splenectomy, and hematopoiesis can all lead to _________ ___________. |
reactive thrombosis |
| Adenocarcinoma, sepsis, and liver disease is most often accompanied by what secondary condition? |
DIC |
mr. charles11
