Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Stack #185898
| Question | Answer |
|---|---|
| Hyperlipidemia & disease states it causes... | Coronary artery disease |
| Where are lipoproteins synthesized? | found in the plasma--transport Triglys & Cholesterol. Syth in intestinal mucosa and liver. |
| Know comp of lipoproteins | IN terms of: Triglys: CH>VLDL>LDL>HDL Protein: HDL>LDL>VLDL>CH Cholesterol: LDL>HDL>VLDL>HDL |
| MOA of Gemfibrozil | Inhibits VLDL synth and increases lipoprotein lipase activity. Lipoprotein lipase stops production of cholesterol in the liver. |
| MOA of Lovastatin | HMG-CoA reductase inhibitor (produces cholesterol in the liver) |
| MOA Cholestraymine | Decreases LDL-Resins that to (-) charged bile acids in the small intestines complex is excreted in the feces. |
| SE if Niacin | fluching/itching |
| Eg of a HmG CoA reductase inhibitor: | Simvastatin, Lovastatin |
| What occurs in the clotting cascade: | St.1: 2 pathways come to the same point: Create/activate factor10-->10A-->prothrombinase St.2: Prothrombinase converts prothrombin to thrombin St. 3: Thrombin--> converts fibrinogen to fibrin=clot. |
| Where does Heparin work on the clotting cascade? | Intrinsic pathway-complexes with naturally occurring antithrombin 3 to enhance its activity. *Protamine is the anitdote. |
| How does warfarin work? | Blood thinner. Prevents DVT, PE and MI. Mimics VK causes body to make abnormal clotting factors. Will lead to excessive bleeding. Low VK foods/no NSAIDS. |
| Low molecular weight Heparins do what? | Accelerates the inhibition of factor 10A. Used to prevent and treat thromboembolisms. Advantages compared to heparin: Long 1/2 life, better SC availibility, home use, reduced monitoring |
| Thrombolytics | Degrades clots that are already formed. Streptokinase-MOA activates plasminogen to plasmin. Also inhibits the formulation of fibrin. |
| Class of Clopidogrel? | Antithrombotic "Plavix" MOA inhibits ADP induced platelet aggregation. |
| How to anticoagulants work? | They inhibit coagulation by antagonizing Vit K in the synthesis of Prothrombin and factors 7,9, and 10 in the liver. (extrinsic) |
| Know the different classes of anticoagulation drugs? | Thrombolytics-clot busters Antithrombotics-Prevent platelet agregation Anticoagulants-Mimics VK |
| Define COPD | COPD-Chronic obstructive pulmonary disease. Obstruction in the respiratory tract. Fibrotic changes in the in the lining of the lungs. No cure |
| Define Emphysema | destruction of the alveolar walls causing holes in lungs. No cure |
| Which system effects GMP & cAMP? | SNS activates stimulation of cAMP PNS activates stimulation of cGMP |
| Theophylline | Xanthine compound found in coffee, tea, cocoa. INhibits an intracellular enzyme Phosphodiesterase. Results in increased levels of cAMP = Broncholdilation |
| Cromolyn sodium | INtereres with the antigen/antibody rxb to release mast cell mediators. Prophylactic-not a bronchodilator. for asthma |
| Mucolytics | chem agents that liquefy bronchial mucus. Acetylcysteine. |
| Expectorants | agents that stimulate the production of respiratory secretions, which then decrease the irritation and cough caused by dryness of the airways . OUtput of respiratory secretion s increased and cough is suppressed. |
| Beta agonists | adrenergic drugs that selectively stimulate the B2 receptors. Eg. albuterol/salmeterol |
| Corticosteroids | for acute inflammation & allergic conditions. MOA inhibit the inlfammatory response that occur in the respiratory airways. |
| What agents stimulate the parietal cell to produce acid? | Gastric acid secretion is stimulated when food enters the stomach--> more acid is secreted by the acid hormone gastrin--> stimulates parietal cells to produce acid. G, ACH. Histamine enter Parietal cell receptors to produce acid. |
| Which drugs are considered GI stimulants? | For treatment of GERD. Metoclopromide-MOA induce contraction in the upper GI tract. Prevents reflux in the esophagus. other MOA: stimulates contraction of the lower esophageal sphincter. |
| Factors that create ulcers | emotional stress, smoking, spicy foods, bacteria, alcohol |
| how do antispasmotics work | For abdominal cramping. Don't exhibit ACH activity. They are used for their ability to relax intestinal smooth muscle. If this works--the cause is emo stress. Dicyclomine |
| How do antacids work? | Pain reliever. MOA neutralized gastric activity. Reacts with hydrochloric acid to form H2O and salt. The H+ ions are used to form water gastric acidity decreases & the pH of the stomach juices increase. |
| name 2 types of ulcers | Duodenal ulcers-food relieves painq Gastric ulcers-food exacerbates pain |
| What are H2 blockers? | H2 blockers-block H2 receptors to prevent activation of parietal cell. |
| Cimetadine/Famotadine | H2 Blockers |
| Sucralfate | "stomach band-aid" Neither an antacid nor an antisecretory drug. Liquid/tablet/suspension. MOA enhances mucosal defense by a local action at the site of the ulcer. |
| Kaolin/pectin | absorbent to treat simple diarrhea |
| Bella donna alkaloids | Anti ACH simple diarrhea |
| Loperimide | Narcotic derivative simple diarrhea |
| Opiates | opium Simple diarrhea |
| How do stimulant laxitives work? Who should not use them? | Directly irritate the mucosal lining of the intestines. Ulcer pts? |
Created by:
manka