| Question |
Answer |
| MOA orlistat |
inhibits pancreatic lipase |
| clinical use of orlistat |
obesity management |
| toxcicity of orlistat |
gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha |
| MOA sibutramine |
sympathommimetic 5HT and NorE reuptake inhibitor |
| uses of sibutramine |
short term and long term obesity management |
| toxicity of sibutramine |
htn tachycardia |
| uses of GH |
GH deficiency turner's syndrome |
| uses of somatostatin |
acromegaly carcinoid gastrinoma glucagonoma |
| uses of octeroitide |
(aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma |
| uses of adh |
pituitary DI |
| MOA propylthiouracil |
inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 --> T3 |
| Which drugs block peptidoglycan cross-linking |
Cephalosporin -cillins -nam/-nem |
| which drugs block peptidoglycan synthesis? |
bacitracin vancomycin cycloserine |
| which drugs block bacterial/fungal cell wall synth |
polymyxins |
| which drugs disrupt fungal cell membranes |
amphotericin b nystatin -azoles |
| which drugs block NT synth |
"Try my cell phone - I blocked the New Cleo" Sulfonamides trimethoprim |
| which drugs block DNA synth |
"TOPless DANcing Queen" (insert abba song here... :) Topoisomerase Quinolones |
| which drugs block mRNA synth |
rifampin |
| Which drugs block protein synth at the 50S subunit? |
-mycins linezolid -gramins macrolides chloramphenicol |
| which drugs block protein synth at the 30S subunit |
Aminoglycosides tetracyclines |
| MOA penicillin |
it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes |
| uses for penicillin |
gram + cocci and rods GNR spirochetes |
| which penicillins are the penicillinase resistant? |
Nafcillin dicloxacillin methicillin |
| clinical uses for penicillinase resistant penicillins? |
S. aureus (except for MRSA) |
| why are penicillinase resistant penicillins resistant to penicillinase |
bulikier R group |
| how is MRSA resistant to methicillin |
altered penicillin binding protein target site |
| adverse reaction to methicillin |
interstitial nephritis |
| examples of aminopenicillins |
ampicillin amoxicillin |
| what is clavulanic acid |
penicillinase inhibitor |
| clinical uses for aminopenicillins |
"ampicillin/amoxicillin HELPS kill enterococci" H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci |
| anti-pseudomonal drugs |
"Take Piper in the Car, Sue" ticarcillin piperacillin carbenicillin |
| MOA cephalosporins |
same as penicillins, less susceptible to penicillinases |
| uses for 1st generation cephalosporins |
PEcK Proteus E coli Klebsiella |
| uses for 2nd generation cephalosporins |
HEN PEcKS H. flu Enterobacter Neisseria Proteus E. coli Klebsiella Serratia |
| examples of 1st generation cephalosporins |
"You FAILed the FIRST PHASE" cefazolin cephalexin |
| examples of 2nd generation cephalosporins |
"Wait a SECOND! You SEE, FOX FUR is a FACt" cefoxitin cefuroxime cefaclor |
| 3rd generation cephalosporins |
"If you are THIRsty, try a FOTO TAZER" Cefotaxime Ceftazidime ceftriaxone |
| clinical uses of aztreonam |
klebsiella pseudomonas serratia (GNR only, nothing against gm + or anaerobes) |
| who is given aztreonam |
penicillin allergic pts pts w renal insuff that can't tolerate aminoglycosides |
| what is cilastatin? |
inhibits renal dihydropeptidase I always administered with imipenem |
| clinical uses for imipenem/meropenem? |
gram + cocci GNR anaerobes |
| toxicity of imipenem, meropenem |
gi distress rash seizures (all occcur at high plasma levels) |
| MOA aminoglycosides 'cidal/static? |
inhibits formation of initiation complex --> misreads mRNA requires O2 for uptake, so won't work against anaerobes 'cidal |
| which drugs are aminoglycosides? |
"Mean GNATS canNOT kill anaerobes" Gentamicin Neomycin Amikacin Tobramycin Streptomycin |
| toxicity of aminoglycosides |
"Mean GNATS canNOT kill anaerobes" Nephrotoxicity (esp if used with cephalosporin) Ototoxicity (esp w/ loop diuretic) Teratogen |
| Uses for tetracyclines |
VACUUM THe BedRoom Tunight V. cholera Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Burgodorferi Rickettsia |
| MOA tetracyclines 'cidal/static? |
binds 30S and prevents attachment of aminoacyl RNA static |
| foods to avoid when takin tetracyclines |
don't take with milk, iron, or antacids b/c it will inhibit absorption in gut |
| which tetracycline is fecally eliminated? |
doxycycline (can be used in renal failure) |
| toxicity of tetracyclines |
photosensitivity gi discomfort discoloration of teeth inhibits bone growth in kids |
| contraindications of tetracyclines |
pregnancy |
| what drug can act as a diuretic in SIADH |
demeclocycline (ADH antagonist) |
HHS Shrek
