USMLE

Description:	Comprehensive Pharm 5
Category:	USMLE
Created by:	Asclepius on 2008-10-22

Question	Answer
class thioridizine	typical antipsychotic
class haloperidol	typical antipsychotic
class fluphenazine	typical antipsychotic
class chlorpromazine	typical antipsychotic
class clozapine	atypical antipsych
Class olazapine	atypical antipsych
class risperidone	atypical antipsych
class fluoxetine	ssri
class paroxetine	ssri
class sertraline	ssri
class citalpram	ssri
class imipramine	tca
class amitriptyline	tca
class desipramine	tca
class nortiptyline	tca
class clomipramine	tca
class doxepin	tca
class buprorpion	heterocyclic
class venlafaxine	heterocyclic
class mirtazapine	heterocyclic
class maprotiline	heterocyclic
class trazadone	heterocyclic
class phenylzine	maoi
class tranylcypromine	maoi
toxicity associated with ssri	gi distress anorgasmi a seratonin syndrome if given with maoi
sx of seratonin syndrome	hyperthermia muscle rigidity cv collapse
how long does it take for antidepressants to work	2-3 wks
side effects of tca	sedation alpha-blocking effects atropine like effects (tachy, urinary retention)
which generation of tca s have more anticholinergic effects? give an example of the drug	3rd amitryptyline
which tca is least sedating	desipramine
toxicity assocaited with tcas	tri-c's convulsions coma cardiotoxicity respiratory depression hyperpyrexia confusion and hallucination in elderly (d/t anticholinergic effects)
which class of drugs is used to treat alcohol w/d	benzos
which class of drugs is used to treat anorexia/bulemia	ssri
which drugs are used to treat anxiety	buspirone benzos/barbiturates (take a shorter time to work) MAOI
which drugs are ssris?	paroxetine fluoxetine sertriline citalopram
which class of drugs is used to treat atypical depression	maoi
which class of drugs is used ot treat bipolar d/o	lithium carbamazepine valproic acid
which drugs are used to treat depression	ssri tca
which drugs are used to treat depression with insomnia	trazadone mirtazapine
which drugs are used totreat OCD	climipramine ssri olanzepine
which drugs are used to treat panic d/o	tca buspirone
toxicity associated with maois	hypertensive crisis associated with ingesting wine/cheese (tyramine)
drug interactions assicated with maois	b-blockers ssri (--> both cause seratonin syndrome)
MOA venlafaxine	inhibits 5HT, NorE, and DA reuptake
toxicity of venlafaxine	stimulant effects sedation nausea constipation increased BP
MOA mirtazapine	alpha-2 antagonist (increased release of NorE and 5HT) and potent 5HT2, 3 receptor antagonist
toxicity of mirtazapine	sedation increased appetite weight gain dry mouth
moa maprotiline	blocks NorE reuptake
toxicity of maprotiline	sedation orthostatic hypotension
moa trazadone	inhibits 5HT reuptake
toxicity of trazadone	sedation nausea priapism postural hypotension
MOA dantroline	blocks the release of ca from SR of skeletal muscles
uses of dantroline	nms malignant hyperthermia
wha tcan cause malignant hyperthermia	inhalation of anesthetics and succinylcholine
what are the different types of NM blocking agents	depolarizing and nondepolarizing
ex of a depolarizing NM blocking agent	succinylcholine
ex of nondepolarizing NM blockign agent	anything with a "cur" in it
uses of NM blockign agents	to paralyze muscles in surgery or mechanical ventilation
what are the 2 phases of depolarizing NM blockade?	1: continuous depolarization 2: gradual repolarization with resistance
how do you reverse the depolarizing blockade at phase 1? phase 2?	administer cholinesterase inhibitors (eg: neostigmine or physostimine) during PHASE
how do you reverse the non-depolarizing blockade?	cholinesterase inhibitors (eg: neostigmine, edrophonium)