| Question |
Answer |
| MOA amphetamine |
indirect general sympathetic agonist releases stored catecholamines |
| MOA epehderine |
indirect and direct sympathomimetic stimulates release of NE from sympathetic neurons |
| MOA cocaine |
blocks reuptake of NorE and DA |
| MOA clonidine |
centrally acting alpha agonist decreased central adregnergic outflow |
| uses for epi |
anaphylaxis glaucoma asthma hypotension |
| uses for norE |
hypotension (but decreases renal perfusion) |
| uses for isoproterenol |
rare... AV block |
| uses for DA |
shock (increases renal perfusion) heart failure |
| uses for dobutamine |
shock heart failure cardiac stress testing |
| uses for amphetamines |
narcolepsy obesity ADD |
| uses for ephedrine |
nasal decongestion urinary incontinence hypotension |
| uses for phenylephrine |
pupil dilator vasoconstriction nasal decongestion |
| uses for albuterol |
asthma |
| uses for terbutaline |
asthma |
| uses for cocaine |
vasoconstriction local anesthetic |
| uses for clonidine |
HTN (esp with renal dz b/c it doesn't decrease blood flow to kidney) |
| examples of inhaled anesthetics |
halothane enflurane isoflurane (-ane) |
| MOA inhaled anesthetics |
unknown |
| effects of inhaled anesthetics |
myocardial depression respiratory depression n/v increased cerebral blood flow decreased cerebral demand |
| toxicity of halothane |
hepatotoxicity |
| toxicity of methoxyflurane |
nephrotoxicity |
| toxicity of enflurane |
pro-convulsant |
| toxicity of any inhaled anesthetic |
malignant hyperthermia (rare) |
| types of drugs used as IV anesthetics |
BB King on optiates proposes foolishly Barbiturates benzos Ketamine (arylclohxamines) opiates Propofol |
| which barbiturate is commonly used as an IV anesthetic? |
thiopental |
| uses of thiopental |
induction of anesthesia short surgical procedures |
| which is the most common anesthetic used for endoscopy? what is it administered with? |
midazolam gaseous anesthetics and narcotics |
| side effects of midazolam |
post-op respiratory depression hypotension amnesia |
| how is the respiratory depression from midazolam treated? |
flumezanil |
| side effects of arylcyclohexamines |
bad dreams CV stimulation disorientation hallucinations increased cerebral blood flow |
| benefit of propofol |
less post-op nausea than thiopental |
| what is combined with opiates during general anesthesia? |
other CNS depressants |
| MOA local anesthetics |
block Na channels by binding to specific receptors in inner portion of channel |
| examples of atypical antipsychotics |
olanzapine clozapine risperidone |
| examples of typical antipsychotics |
thioridazine haloperidol fluphenazine chlorpromazine |
| MOA typical antipsychotics |
block D2 receptor |
| MOA atypical antipsychotics |
blocks dopamine and 5HT receptors |
| clinical uses of typical antipsychotics |
schizophrenia psychosis acute mania Tourette's |
| clinical uses for atypical antipsychotics |
schizophrenia (+ and - sx) |
| clinical uses for olanzapine |
OCD anxiety d/o depression mania Tourette |
| toxicity associated with typical antipsychotics |
EPS endocrine effects anti-muscarinic effects (dry mouth) hypotension (from blocking alpha receptors), sedation (from blocking histamine receptors) NMS tardive dyskinesia |
| what is tardive dyskinesia |
stereotypical oral-facial movements d/t blocking DA receptors |
| what is NMS |
rigidity myoglobinuria autonomic instability hyperpyrexia |
| tx of NMS |
dantrolene and DA agonists |
| toxicity associated wiht atypical antipsychotics |
less EPS and anti-cholinergic effects Clozapine --> agranulocytosis |
| uses for lithium |
bipolar blocks relapse and acute manic events |
| toxicity of lithium |
LMNOP movement (tremor) nephrogenic DI hypOthyroidism Pregnancy problems |
| MOA buspirone |
stimulates 5HT1a receptors |
| uses of buspirone |
anxiolysis for GAD |
| benefits of buspirone |
doesnt cause sedation or addiction doens't interfere with alcohol |
| examples of ssri's |
fluoxetine sertraline paroxetine citalopram |
| clincical uses for ssri |
OCD endogenous depression eating d/o |
| examples of tricyclic antidepressants |
imipramine amitriptyline desipramine nortiptyline clomipramine doxepin |
| MOA TCA |
blocks reuptake of NorE and 5HT |
| uses for TCAs |
major depression bedwetting (imipramine) OCD (clomipramine) |
| which TCA is used for bedwetting |
imipramine |
| which TCA is used for OCD |
clomipramine |
| examples of heterocyclic anti-depressants |
you need BUtane in your VEINs to MURder for a MAP of alcaTRAZ buproprion venlafaxine mirtazapine maportiline trazodone |
| examples of MAOIs |
phenelzine tranylcypromine |
Science Vocab 147928
