| SLE |
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| Systemic lupus erythematosus |
chronic inflammatory condition affecting joint surfaces and vessel walls seen predominantly in women and young children |
genetic predisposition , seen in relatives with HLADR2 and HLADR3 antigens |
most common immunologic feature is production of ANA- immune complexes responsible for renal and cutaneous manifistations, tissue specific antibodies that cause hemolysis(RBC break down=brown urine) and thrombocytopenia(decreased platelets bleed rightaway |
effects joints and kidneys, serous surfaces, and vessel walls |
etiology is unkown |
ANA + |
| systemic manifestations include |
fatigue |
malaise |
weight loss |
fecer without signs of infection |
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| cutaneous manifestations |
malar or butterfly rash exacerbated by exposure to sun |
discoid rash ( chicken skin) |
patchy alopecia (regional balding) |
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| joint manifestations |
arthritis- symmetric primarily involving hands, wrist , and knees |
ligament laxity leads to joint deformaties |
raynaud's phenomenon - alternate red and whitediscoloration of skin secondary to exposure to cold weather |
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| renal manifistation |
nephritic syndrome (Blood urea Nitrogen increases, lipid loss causes hypolipidemia, sensorial deterioration so drowsy and comatose, decrease albumin increases edema) |
renal failure ( can't produce urin) |
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| neurologic manifistation |
behavioral and cognitive disturbances |
activive cerebritis( encephalitis) |
neuropathies cranial and peripheral |
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| git manifestation |
nasea |
abdominal pain 2 to steril peritonitis |
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| Cardio pulmonary manifestation |
pleuritis ( infl lung tissue) |
pneumonitis ( infl lung) |
pericarditis |
endocarditis ( infl of heart valves) |
(Libman sacs endocarditis) |
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| hematologic manifestation |
hepatosplenomegaly |
normochronic, normocytic anemeia ( normal number and size of rbc can't sustain O2 |
leukopenia ( dec WBC) |
thrombocytopenia ( dec platelets) |
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| treatment |
steroids and cytotoxic agents ( azthioprine , cyclophosphomide) for ppl with kidney problems, hemolytic anemia, and thrombocytopenia |
antimalarial agent for cutaneus manifistation and arthritis 9 hydroxycloroquin) |
analgesics like ASA, NSAID, or ibuprofin for mild systemic symptoms |
side effect of acytyl salilic acid is salycylate hepatitis |
side effect for nsaid is acute renal failure |
side effect for ibuprofin is aseptic meningitis |
Ch.18 LTI-MA 509
