| Immunologic Disorders |
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2 |
3 |
4 |
5 |
6 |
| Cellular immunity |
T cells or lymphocytes |
Helper induce T cell, cytotoxic or killer t cell, supressor t cell, supressor inducer t cell |
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| Humoral immunity |
B cells or lymphocytes |
IgM, IgA,IgG, IgE, IgD |
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| Tests for cellular immunity |
Quantitative ( lymphocyte count, T cell subset (CD4, CD8), NK cell numbers) |
Qualitative (DTH skin test, ability to elaborate cytokines ( IL1,2,4, TNF) |
Ability to generate MHC-restrict CTL |
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| Tests for humoral immune response |
serum immunoglobulin levels |
determination of isohemagglutinin and febrile agglutinin titers |
determination of antibody titers following immunization with tetanus toxoids, diphtheria toxoid, or pneumococcal polysaccharide vaccines |
protein electrophoreisis( albumin,globulin,fibrinogen) |
immunoelectrophoreisis |
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| Disorders of immunoglobulin overproduction |
MGUS |
multiple myeloma |
waldenstrom macroglobulinemia |
Amyloidosis |
heavy chain disease |
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| Primary Immunologic Difficiency Disorder |
selective IgA deficiency |
Bruton's X linked, Degeorge thymic hypoplasia |
chronic mucocutaneous candidiasis |
Wiskott-aldrich syndrome |
chronic granulomatous disease (inability tto develope neutrophils |
ataxia and aids |
| Secondary Immunologic Difficiency Disorders |
AIDS |
iatrogenic ( cancer chemotherapy) |
immunodificiency associated with Sarcoidosis and Hodgkins |
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| Cell mediated autoimmunity |
SLE |
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| Antibody-mediated autoimmunity |
hemolytic anemia |
idiopathic thrombocytopenia |
goodpasture's syndrom |
grave's disease |
myasthenia gravis |
type 1 DM |
| Immune complex disease |
SLE |
rhumatoid arthritis |
drug induced hemolytic anemia |
drug induced thrombocytopenia |
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| Diagnosis |
agglutination of antigen-coated RBC |
Enzyme-linked immunoassays (ELISA) |
immunoflourescence microscopy |
complement fixation |
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| Treatment |
supression of autoantibody productions (corticosteroids, cytotoxic agents) |
relieve tissue damage from immune complexes (ASA,NSAID,colchine, corticosteroids) |
remove offending autoantibodies and circulating immunecomplexes (cytotoxic drugs) |
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BIOL3326 Forms
