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Hospital Acquired
Infections
| Question | Answer |
|---|---|
| Psuedomonas Aeruginosa | Gram Negative |
| Staphylococcus Aureus | Gram Positive |
| Inhibitors of 30S ribosomal subunit | Aminoglycocides |
| For P.aer, S. Aur | Aminoglycocides |
| 3 Major steps in Cell Wall Biosynthesis | Syn of murein monomers, Polymerization of murein Monomers, Cross linking of polymers |
| Streptococcus Pneumoniae | Gram Positive |
| Ampicillin | Hydrophilic |
| Amoxicillin | Hydrophilic |
| Pipercillin | Hydrophilic |
| Ticarcillin | Hydrophilic |
| Oxicillin | Hydrophobic |
| Cloxacillin | Hydrophobic |
| Methicillin | Hydrophobic |
| Penicillin G | Hydrophobic |
| Oxacillin | Hydrophobic - Semi-Synthetic Penicillin |
| Cloxacillin | Hydrophobic - Semi-Synthetic Penicillin |
| Dicloxacillin | Hydrophobic - Semi-Synthetic Penicillin |
| Nafcillin | Hydrophobic - Semi-Synthetic Penicillin |
| Mathicillin | Hydrophobic - Semi-Synthetic Penicillin |
| 1st Gen based on bacterial susceptibility | Cephazolin, Cefalexin, Cefradine (Cephalosporins) |
| 2nd Gen based on bacterial susceptibility | ? |
| 3rd Gen based on bacterial susceptibility | Ceftazidime, Cefizoxime, Cefoperazome |
| 4th Gen based on bacterial susceptibility | Cefeprime |
| Which Cephalosporins cause alcohol intolerance and increase clotting time | Cefotetan, Cefamandole, Cefoperazone |
| Vancomycin - MOA | Inhibit transglycosidation |
| Streptomycin | Obtained from streptomyces |
| Neomycin | Obtained from streptomyces |
| Kanamycin | Obtained from streptomyces |
| Tobramycin | Obtained from streptomyces |
| Amikacin | Obtained from micromonospora |
| Gentamicin | Obtained from micromonospora |
| which type of drugs are used for all three bacteria | penicillins and cephalosporins |
| what drug is used against methicillin resistant staphylococcus aureus | vancomycin |
| aminoglycosides are affective against | pseudomonas aeruginosa, staphylococcus aureus (NOT PNEUMONIAE) |
| three beta lactamase inhibitors | clavulanic acid, sulbactam tazobactam |
| what is the target of beta lactam antibiotics | transpeptidase |
| which type postive or neg have thick coat of murein | positive |
| which type of substances can easily pass through gram positive murine coat | hydrophilic |
| which + or - have a lipoteichoic acids for feeding, protection and adherence | gram + |
| Gram negative bacteria turn what color when stained with crystal violet | pink |
| which type - or + have thin coat of murein between two lipid bilayers | gram negative bacteria |
| which type + or - have lipoolysaccharides for protection adherence. (notice not say feeding) | gram negative bacteria |
| which type + or - can easily evade the host immune system do to pores and beta lactamases beging inside | gram negative |
| where does the synthesis of the murein monomer occur | intracellular in the cytoplasm |
| a murein is made of what | sugars and amino acids |
| where does the polymerization of murien monomers happen | cytoplasmic membrane because it is lipid mediated |
| where does cross linking of polymers in 2D lattices and 3D mats: | extracellular, in the periplasmic space between cytoplasmic membrane and murein layer |
| in which order are the sugar monomers formed | NAG then NAM |
| how does the rx of cell wall synthesis carried out | amidation,phosphorylation, acetylation,and addition rxn |
| what is the next step in cell wall biosynthesis after monomers are formed | the addition of peptide components alanine, glutamate, lysine (if neg DAP instead of lysine) |
| what is the last rxn before forming the park pepide | d-alanyl-D-alanine dipeptide added to UDP-NAM peptide to form park peptide by enzyme MurF |
Created by:
lainylaina