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Stack #138507
| Question | Answer |
|---|---|
| deltamethrin LD50 po | 30-300mg/kg |
| Deltamethrin dermal (insecticide chalk) | > 2000mg/kg |
| DEET | N,N-diethyl-meta-toluamide |
| picaridin (avon skin so soft, bug guard, cutter advanced 3-5 hours of effectiveness | 2-(2-ydroxyethyl) piperidinecarboxylic 1-methylpropyl ESTER |
| permethrin botanical insecticide ADI (pyrethrin 1, resmethrin, allethrin | 0.05 mg/kg toxicity includes hyperexcitation, aggressiveness, startle response |
| deltamethrin ADI (other type two include cypermethrin, fenvalerate | 0.01mg/kg toxicity: clinic seizures, wrihing |
| carbamate anticholinesterases | baygon, zectran, aldicarb temik, carbaryl(sevin) |
| acetylcholine work by | acetylation |
| organophates work by | phosphorylation |
| carbamamates work by | arbamylation |
| malathion (P-S bond) is inactivate by | hydrolysis |
| malaoxon (P-O bond) is inactivated by | ACHE inhibition |
| ANTIDOTAL treatment for anticholinesterase poisoning is | atropine (blocks ACHE receptors) OXIME (protopam/cholinesterase reactivator), diasepam, support respiration because this is primary cause of death |
| organophosphates MOA with acetylcholine reactivation the K3 is | ultra rapid |
| organophosphates MOA k3 | very slow |
| parathion with MFO in liver gives | paraoxon |
| ACHE-paraoxan is | spontaneously reversible |
| once paraoxon has be diethyl-phosphorlated ACHE it was become aged AGED-CHE and is not longer reversible there is no K$ with acethycholine | if put a flurin group there is no change to reverse |
| the K3 of Paraoxon MOA may require what as an antidote | oxime antiodote |
| tetraethyl pyrophosphate TEPP oral and dermal LD 50 is | 1.1/2.4 |
| parathion LD 50 rat (oral / dermal | 13/21 |
| malathion rat LD50 oral/dermal | 1375/>4000 |
| DDVP dichiorvos LD50 (used in flea colars, past) | 80/107 |
| tricholorofon LD50 | 630/2000 |
| methoxychlor requires P450 rxn its half life and LD50 are | 2 week t1/2 and >6000mg/kg chance of resistance to those with p450 because this is the way it is rapidly cleared |
| as you move up the ecosytem food chain you get bomagnnification and boactive body burdens can accumulated as much | 345 times |
| DDT has what kind of activity and is responsible for resproductive issues in animals and birds | estrogenic |
| DDT and its metablolite is very lipid soluable and stay is the fat the metabolite are (DDE adn DDD) not DDA with is excreted in urine the half life of DDT is | 1/2 to 1 year is the mammalin half life |
| the oral LD 50 of DDT is | 100-250 mg/kg |
| the enzyme dehydrocholorinase will change DDT to lipid soluable form with a LD50 of | 880mg/kg |
| DDT will make metabolite that can be excreted in the urine with a LD 50 of | 740 mg/kg |
| oragnophosphates and carbamates MOA and target is | inhibition on ACHE |
| phyrethroids (I and II), DDT MOA and targe | activation of sodium sodium channels |
| dihyropyrazoles MOA and Target | inhibition and sodium channels |
| rotenoids MOA and target | inhibition of mitochdrial comples I |
| pyrethroids type II aslo MOA and targe | inhibition of GABA receptors-gated chloride channels |
| a mechanistic attack that is used pyrethrioid resistance is MFO inhibitors and an examples is | piperonly butoxide that blocks the p450 detox |
Created by:
lainylaina