Epinephrine at Work
| Description: | How epinephrine/norepinephrine work on cardiac mysoties themselves |
| Category: | Physiology |
| Created by: | zeenat on 2008-03-03 |
| Question | Answer |
| STEP 1 | Binding of epinephrine/norepinephrine changes shape of beta receptor -> activates G-Protein |
| STEP 2 | G-Protein subunit activates adenylate cyclase |
| STEP 3 | Adenylate cyclase catalyzes conversion of ATP to cAMP |
| STEP 4 | cAMP activates protein kinase A |
| STEP 5 | Protein kinase phosphorylates Calcium channels, influx on calcium in cell, stimulates contraction |
| STEP 6 | protein kinase also phosphorylates calcium channels on sarcoplasmic reticulum. calcium then moves into the cytoplasm and stimulates contraction. |
| STEP 7 | Protein kinase phosphorylates myosin, stimulates contraction |
| STEP 8 | Protein kinase phosphorylates sarcoplasmic Calcium ATPase -> speeds removal of calcium from cytoplasm during relaxtion. decreases over relaxtion time. |
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