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patho
Stack #120767
| Question | Answer |
|---|---|
| Neurodegenerative Diseases | Alzheimer's, ALS, Lou Gerhig's, Huntington's, Parkinson's |
| Causes of Deficits in Brain data processing | Injury, toxins, disinhibition |
| Most common from of dementia | Alz |
| Characteristic of Alz | Neurofibrillary Tangles and beta-amyloid Plaques |
| Theory of Alz | Inflammation response activated which kills all cells the area |
| Is it normal to have tangles? | Yes, they are part of the cytoskeleton |
| Is it normal to have plaques? | Yes, everyone has them |
| ______ is correlated to Alz. severity. | Tangles |
| Normal Tau protein uses | make microtubles, transport nutrients |
| The normal Tau protein is capped or uncapped. | capped to give it stability |
| bAAP | beta amyloid |
| bAAP gene is found on what chromosome | 21 |
| bAAP leaves a fragment of what? | APP - protein amyloid precursor protein |
| Protein snipets are cleaned up in the Alz. brain? | no they clot and from amyloid plaques |
| Amyloid plaques gather where? | Between nerve cells |
| Amyloid plaque properites | insoluble, hard |
| Formation of B-amyloid plaques is a result from what? | missprocessing which lead to accumaltion of toxic levels of b-fragments |
| ____ and ____ possibly activate the inflammation response. | Free radicals and b-amyloid plaques |
| Cause of Alz | Genetic (apo E), Toxic exposure, Nutritional Disorders, Free Radicals |
| Apo E (Apoliprotein E) normally... | is a carrier of cholesterol in the blood |
| Mutated ApoE binds to.... | b-amyloid (makes it insolube) and Tau |
| The ventricals in an Alz brain are.. | Larger |
| Nutritional deficets that might lead to Alz. | Vit E, B12, Thiamin, Zinc, Acetyl 1-carnitine |
| Areas affected by Alz | Cereberal Cortex ( Frontal Lobe) and Hippocampus (brain stem) as well as cholingeric neurons |
| The Cerebral Cortex is where we find.. | reasoning, memory and learning |
| The temporal lobe is where we find... | memory formation |
| The Ventricles of an Alz brain are... | larger |
| Cholinergic neurons degenerated within... | 18 months |
| Gyri size in a Alz brain is.... | enlarged |
| The only Rx for Alz now | Aricept |
| Risk of Aricept | Brings ct back to place of awareness of actually having alz |
| Over time these skills/ areas are effected by Alz | language memory |
Created by:
jamilah