| Drug Name |
Class/Effects/Action |
| Phenylephrine |
sympathomimetic (alpha-1 agonist) tx-HT, nasal congestion |
| Beclomethasone |
corticosteroid - inhaled (less systemic side effects) |
| Clonidine |
sympathomimetic - alpha 2 agonist. tx-HT |
| Theophylline |
long acting bronchodilator (phosphodiesterase inhibitor) tx-asthma |
| Terbutaline |
sympathomimetic - beta 2 agonist. tx-asthma, emphysema |
| Metoprolol |
sympatholytic - beta 1 blocker (agonist) tx-HT |
| Yohimbine |
sympatholytic - alpha 2 antgonist. tx-erectile dys. produce mydriasis |
| prazosin |
sympatholytic - alpha 1 blocker (antagonist) tx-HT |
| Dobutamine |
sympathomimetic - beta 1 agonist. tx-cardiac decomposition |
| Fluticasone |
corticosteroid (inhaled) - less systemic side effects |
| Prednisone |
corticosteroid (systemic) |
| Four classes of long acting bronchodilators |
1. inflammatory mediators inhibitor 2. beta adrinergic agonists 3. leukotriene antagonists 4. phosphodiesterase inhibitors |
| mediators that actively constrict smooth muscle (4) |
histamine, seratonin, platelet activating factor, leukotrienes |
| receptors that NE and Epi act on |
beta 1 and 2; alpha 1 and 2 adrinergic receptors |
| receptors that Ach acts on & ultimate effect in the airway |
M1 and M2 receptors (smooth muscle contraction in airway) |
| Digoxin |
cardiac glycoside - increases contractlity by increasing intracellular [Ca++] tx-heart failure |
| Dopamine |
Dopamine agonist low doses: incr. CO, TPR, venous tone. High doses: incr. TPR, pulmonary vascular resistance, produces vasoconstriction |
| positive inotropes |
improve cardiac function by increasing contractility. drug classes: beta adrinergic, dopamine agonists, phosphodiesterase inhibitors, cardiac glycosides tx-heart failure |
| cardiac antihypertensives |
decrease afterload of heart. beta blockers, Ca++ channel blockers tx-HT, heart failure |
| beta adrinergic agonists - prototype drugs (3) |
isoproteronol (B1 and 2), Dobutamine (B1), Terbutaline (B2) |
| Dobutamine |
Beta 1 adrinergic agonist (cardioselective) tx-cardiogenic shock, heart failure |
| Terbutaline |
Beta 2 adrinergic agonist Tx- asthma, emphysema |
| Isoproteronol |
Beta 1 and 2 adrinergic agonist (not cardioselective) |
| Milnirone |
phosphodiesterase inhibitor (results in incresed Ca++ release) tx-heart failure, pulmonary problems |
| Brimonidine |
sympathomimetic - alpha 2 agonist tx. HT |
| Norephinephrine |
alpha 1 agonist - vasoconstrictor tx-hypovolemia |
| prazosin |
aplha 1 blocker (causes vasodilation) tx-HT |
| Clonidine |
alpha 2 antagonist - sympatholytic - tx-HT |
| Furosemide |
Diuretic - decr. blood volume tx-HT, edema, CHF, renal failure |
| positive inotropes |
increase contractility to increase BP (classes: Beta adrinergic and dopamine agonists) tx-circulatory shock |
| mecamylamine |
ganglionic blocker, nicotinic antagonist tx-severe hypertension (crisis), BP control during aortic surgery |
| Tolcapone |
COMT inhibitor - leads to incr. brain [dopamine] tx-parkinsons |
| Verapamil |
Ca++ channel blocker (most potent negative chronotrope, inotrope, dromotrope) tx-hypertension |
| Propanolol |
B1 and B2 blocker (noncardioselective w/o ISA) |
| Zafirlukast |
long acting bronchodilator (anti-inflammatory) blocks leukotriene receptors. tx-asthma |
| Montelukast |
long acting bronchodilator (antiinflammatory), leukotriene antagonist tx-asthma |
| Salmeterol |
long acting bronchodilator, B2 agonist, tx-asthma |
| Pindolol |
B1 and 2 blocker (noncardiselective w/ISA) |
| Atenolol |
B1 blocker (cardioselective w/o ISA) |
| Acebutolol |
B1 blocker (cardioselective w/ISA) |
| Propanolol |
B1 and B2 blocker (NON cardioselective) tx-HT |
| Atropine |
Anthicholinergetic (muscarinic antagonist) tx-produce mydriasis, decr. airway secretions during intubation |
| Tolterodine |
anticholinergic (muscarininc antagonist) tx-overactive bladder |
| Sites of adrinergic drug action (6) |
1. synthesis 2. vesicular packaging 3. release 4. receptor binding 5. re-uptake 6. metabolism |
| Metyrosine |
blocks synthesis of NE tx-pheocromacytoma (causes HT) |
| Reserpine |
blocks vesicular packaging of NE tx-Ht |
| Desipramine |
TriCyclicAntidepressant: blocks reuptake of NE tx-depression |
| Isocarboxazid |
MAO inhibitor: inactivates excessice neurotransmitters tx-depression |
| Demecarium |
cholinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, open angle glaucoma |
| Ambenonium |
chlinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, glaucoma |
| Pilocarpine |
Cholinomimetic (Ach agonist) Tx-occular HT, glaucoma |
| Albuterol |
B agonist: rapid acting bronchodilator tx-asthma |
| Ipratropium bromide |
Anticholinergic - rapid acting bronchodilator Tx-asthma |
| Pancuronium |
ganglionic blocker, Ach antagonist Tx-hypertensive crisis, control in surgery on aortic aneurism/surgery on blood vessels |
| cardiac effects of Ach |
parasympathetic response (decr. HR, Decr. contractility) MOA-activation of K+ channels, inhibittion of Ca++ channels, adenylyl cyclase |
| Cardiac effects of NE/Epi |
sypathetic response - incr. HR, inr. contractility MOA - activate adenyly cyclase, activate Ca++ channels |
| Sundilac |
anaglesic, antipyretic, anti-inflammatory. Active sulfide metabolite. |
| Ketorolac |
analgesic in ER for suspected opiod users, available in parenteral form |
| DMARD stands for? |
Disease Modifying Anti Rheumatoid arthritis Drugs |
| Methotrexate |
synthetic DMARD. Tx-RA |
| Infliximab |
biological DMARD, inhibits TNF-alpha (inflammatory mediator) |
| Anakinra |
inhibits IL-1 tx-RA |
Buen Viaje lv.2 ch 8
