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Stack #108809
| Question | Answer |
|---|---|
| most resistant glass type for parenteral | type 1 |
| three problems that could occur with plastics are ___-when the drug disolves the plastic and creates a hole,___-components of the container move into the contents, and ___-is where molecules bind to plastic | permeability, leaching, and sorption |
| of crystalline or amorphous with has a definite MP | cystalline |
| of crystalline or amorphous with is more soluble meaning less stable | amorphous |
| crystalline has ____arranged particles while amorphous has ____molecules | orderly, random |
| liquids cannot be formulated into solids with the exception of ____ and _____ | nitroglycerine and scopolamine (put it in its salt form |
| to increase the dissolution rate what do you need to do to particle size | decrease it |
| to increase bioavalibility what do you need to do to particle size | decrease it |
| if you decrease particle size all of the following will increase except dissolution rate, bioavailbility, or solubility | solubility is never associated with particle size |
| what it the biggest problem for drugs? bioavailibility or solubility | solubility |
| what is often the rate limiting step of drugs | dissolution rate |
| if a drug is insoluble what could you do to give it some aqueous solubility for therapeutic efficacy and enter systemic circulation | turn inot salt or ester form |
| which solubility class has high permeablity and high solubility | class one |
| the time it takes for a drug to dissolve in fluids at absorption site is referred to as | dissolution rate |
| what is a could estimate of membrance permeability | partition coefficient- measures how hydro-philic or phobic a drug is in octanol or water |
| if a drug has a high Partition coefficient is would preferentially distribute to hydro_____areas | hydrophobic areas the lipid bilayer |
| low partition coefficient with go to hydro___ areas | hydrophilic ares like blook serum |
| if a liquid drug is suseptable to hydrolysis you should | substitute with glycerin, propylene glycol, or alcohol |
| if an injectable drug is susceptible to hydrolysis you should use ___as solvent | anhydrous vegetable oils |
| if an antibiotic is susceptable to hydrolysis you should | not reconstitute until ready for use and refrig. |
| must drugs are stable at what pH? what could you use to increase stability | pH of 5-6 use a buffering agent to increase stability |
| all of the following are signs the drugs have been oxidize except: changed color, precipitation, producing an odor, or changed in molecular weight | the lose of electron won't change the MW. |
| an antioxidant use to prevent progression of chain reaction in aqueous solutions are the use of | sulfates such as sodium sulfate at high ph, sodium bisulfate(med), and sodium metabisulfate at low pH |
| examples of antioxidants that can be used to prevent oxidation in oleaginous preparations are | alphatocopherol and butyl hydroxyanisole |
Created by:
lainylaina