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Renal2-Clin Med 3

Sustained proteinuria of _____ is common in glomerular disease >1-2g/24hours
What are the three major syndromes of glomerular disease? Nephritic syndrome, nephrotic syndrome, asymptomatic renal disease
Primary renal disease where there are only renal abnormalities
Secondary renal disease where renal disease is secondary to a systemic disease
Etiology of glomerular dz Idiopathic, infection, autoimmune disease (SLE, Goodpasture's), atherosclerosis, *hypertension, *diabetes mellitus
Glomerularnephritis definition Inflammation of the glomerular capillaries
Describe immune mediated glomerulonephritis immune deposits along the GBM causes anti-GBM antibodies to be produced. They trigger the immune cascade. The cytokines released cause destruction of capillary and mesangium
Systemic hypertension and atherosclerosis can be the cause of Chronic glomerulosclerosis
Primary disturbance noted in glomerulonephritis blood in the urine
Malignant hypertension leads to fibrinoid necrosis of arterioles and glomeruli leading to... Acute renal failure
Long-standing effects of hyperglycemia will lead to... Thickening of the GBM
two mechanisms that are affected by changes in vascular resistance Decreased perfusion leads to ischemic injury; Impairment of glomerular arterial outflow leads to intraglomerular hypertension. ultimately Acute and Chronic Tubular Interstitial Nephropathy
Swelling is caused by the (excess/lack of) albumin? lack of.
Lab results/UA of glomerulonephritis RBC Casts, dysmorphic RBC, proteinuria >1-2g/24hrs.
Benign proteinuria (<1gm/24hrs) is present in fever, exercise, pregnancy, obesity
Describe the urine and patient condition in GD urine is foamy, and patient is edematous
Minimal change dz excretion children with minimal change dz excrete only albumin
Acute Nephritic Syndrome Proteinuria, hematuria, pyuria, hypertension, fluid retention, gradual rise in creatinine
6 types of nephritic syndrome RPGN (Cresentic GN), Post streptococcal GN, endocarditis associated GN, Lupus nephritis, Antiglomerular basement membrane dz (Good pasture's syndrome), IgA nephropathy (Berger's Dz)
Rapidly Progressive Glomerular Nephritis the Cresentic GN is a variety of RPGN with a characteristic glomerular lesion
Post Streptococcal GN usu. in the pediatric patients 2-14
4 types of nephrotic syndrome Minimal change disease, membranous nephropathy, membranoproliferative GN, Focal glomerular sclerosis
Created by: Colter