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Pharmacology Test
Question | Answer |
---|---|
Drug | any chemical substance that produces a biologic response in a living system |
Ampule | sealed glass container designed to hold a single dose of a drug. |
Vial | small glass bottle with a sealed rubber cap |
Medication Properties | absorption, distribution, metabolism, excretion,pharmacokinetics,bioavailabilty |
Absorption | process by which a drug enters the systemic circulation in order to provide a desired effect |
Distribution | means by which a drug travels from the site of absorption to the site of action, usually through the blood stream. |
Metabolism | process by which the body transforms drugs into an inactive form that can be excreted through the body. |
Excretion | elimination of drugs from the body after they have been metabolized. (primarily by the kidneys) |
Pharmacokinetics | how drugs enter the body, are absorbed, reach their site of action, are matabolized, and exit the body |
Bioavailabity | when a drug must be absorbed and taken via the bloodstream to its intended site in order to act |
The amount of time needed to absorb a drug and the extent to where it becomes bioavailable deoends on ___? | Route of administration, GI Motility, Dosage Form, Interaction with food & other drugs |
Medication Effect: Therapeutic effect | predictable physiological response |
Side Effect | response other than the desired effect |
Adverse Effect | Unwanted "bad" effect, Meperdine (demerol) frequently produces nausea & vomiting |
Toxic Effect | developes when a drug accumulates in a body beacause of inadequate excretion, impaired metabolism, overdose, or drug sensitivity. |
Idiosyncratic Effect | When a pt over or under reacts to a drug or has an unusual reaction |
First-pass Effect | Partial metabolism of a drug before it reaches systemic circulation |
Clearance Rate | A drug's removal from the body |
Biological Half Life | time required for a current serum drug concentration to decline by 50% (half life of heparine is 90 min while half life of coumadin is 48hrs) Liver function can effect half life. |
Allergic Reaction | results from an immune medicattion response by the body against the drug and is not necessarily related to dose. |
Drug-Drug interaction | occurs when 2 or more drugs act in unison, may produce bad effects (contrast & metformin) or may produce a synergistic effect (alcohol & valum) where the sedative properties of the 2 drugs could combine and cause a comatose state |
FDA | Federal agency that is responsible for protection against fraudulent claims by manufactures or merchants of foods or drugs, allows the name to be shortened for ease of memory. Food & Drug Administration |
Legend Drugs | Medications that require a prescription |
7 Components of a Prescription | Pt name, id#, rm#, or address; drug name (generic or brand); dosage;dosage form; route of administration; date order is written; prescribers signature |
Verbal Order | an order that is verbally recieved form a physician & transcribed to an order form, must be signed. |
Drug Classifications | Chemical name, Generic name, Brand/Trade name |
Controlled substances | Meds that have high potential for abuse; classified by "C", roman numerals donates class, range from C-1 through C-V |
C-1 drugs | opium, heroin, cocaine= illegal |
C-V Drugs | Can be purchased OTC w signature |
C-11 drugs | only legal with prescription; high potentail for abuse, stored under lock & key (morphine, fentanyl, & oxycodone) |
Analgesics | Drugs that releive pain without causin LOC. Non-narcotics used to treat pain (tylenol,acetaminophen), & treat inflammation (ibuprofen-advil, naproxen-aleve) |
Analgesics-Narcotics | stimulate CNS receptors & cause decrease in the preception of pain. Highly addictive, cause N&V, require prescription. (Morphine, Demerol, fentanyl) |
Anesthetics | Act on CNS to cause loss of sensation. |
General aneshesia | produces muscle realxion & LOC |
Local Anesthesia | Blocks the nerve conduction from the area to the CNS. (Lydocaine-Xylocaine) |
Antianxiety | Calms pt without depressing CNS, or elevates pt mood without depressing CNS, may cause physiologic dependecy with prolonged use & possible sever withdrawel reactions. (Diazepam-Valum) |
Antiarrythmics | Used to treat variations from normal heart beat. (lidocaine-xylocaine, verapamil-Veraptin, Adenosine-Adenocard, Digoxin-Lanoxsin) |
Antiobiotics | Destroy or inhibit the growth of microorganisms, pt may have an allergic reaction. (erythromycin-Erthrocin) |
Anticholinergics | Reduce smooth muscle tone, motility of the GI tract, and secretions from the respiratory tract and secretory glands, Cause dry mouth and decreased perspiration, High doses may produce serious side effects; delirium, rapid heart beat, and coma. Belladona |
Anticoagulants | Inhibits blood clotting or increases coagulation time. Heparine(Hep-Lock) givin IV,Warfarin(Coumadine) oral tablet, enoxaparin(Lovinox)subQ |
Anticonvulsants | prevents or controlls seizures. Clonazpam(klonopin)-petit mal seizures, phenytoin(Dilantin)-grand mal seizures, Lorazpam(Ativan) |
Antidepressants | used to treat clinical depression, enhance levels of seratonin & norepinephrine, may cause dependency.Prozac, zoloft |
Antidiabetic | Required for patients that have difficulty maintaining the proper balance between blood sugar and tissue sugar,Insulin dependent (Type I)-have little or no circulating endogenous insulin,Most take insulin and require regular meals to keep their blood suga |