Busy. Please wait.

Forgot Password?

Don't have an account?  Sign up 

show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.

Already a StudyStack user? Log In

Reset Password
Enter the email address associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know (0)
Know (0)
remaining cards (0)
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Hematology General 2


Hx HTN, nephrotic syndrome, CRF or Renal insufficiency; do CBC: Anemia
PICA, Pregnant & fatigue, Menstruation; cheilosis: Fe Deficiency Anemia
Anemia after colectomy, partial gastrectomy; glossitis, decreased vibratory sensation = B12 or Pernicious anemia
G6PD + Quinidine, Nitrofurantoin, Sulfa, fava beans => Hemolytic anemia
Fatigue, weakness, low fever, purpura, pallor, gingival bleeding; low retic; no HSM: Aplastic anemia
Post showering pruritis, plethora, dyspnea, HA, visual disturbance, tinnitus; splenomegaly, engorged retinal veins; thromboses, high H&H Polycythemia vera; Tx: Phlebotomy
Spontaneous Hemarthrosis Hemophilia A
Mucosal or gingival bleeding, epistaxis, menorrhagia Von Willebrand dz
Continuous bleeding post-op or trauma; pt given multiple blood transfusions; low platelets, increased PT, INR, + fibrin split products (increased d-dimer): DIC
JAK-2 mutation P. vera (97% of pts); Essential Thrombocytosis (50%)
HIT types I (non immune mediated): 100K plts, no thrombosis (dc hep); II (immune med): 30K plts, thrombosis risk (req dc hep, rx direct thrombin inhibs & warfarin)
Coag pathways Intrinsic 12, 11, 9, 8; extrinsic 7; common 1,2,5, 10
thrombopathy genetics von W auto dom; Glanzmann or B-S auto recessive
Trousseau syndrome subacute DIC in cancer pts
hemophilia A x linked rec; male only; 1 in 10K; low VIIIc (corrects w/mixing study); spont hemarthrosis; Rx replace factor, DDAVP
hemophilia B Xmas dz; x linked rec, males; low IX, long PTT; NO ASPIRIN or DDAVP
hemophilia C factor XI: x linked recessive, Ashkenazi; long PTT; rx FFP
Vit K-dept factors 2, 7, 9, 10
heritable hypercoagulable states Factor V Leiden; pro C & S def; antithrombin III def
Hereditary resistance to action of activated protein C = Factor V Leiden (APC resistance)
Deficiency allows unopposed conversion of fibrinogen to fibrin = Antithrombin III deficiency
giant plts; auto rec; no von W factors Bernard-Soulier dz
IgG antibody to PF4: seen in: HIT (both art & venous thrombosis)
Microangiopathic hemolytic anemia & thrombocytopenia without an identifiable cause = TTP (also often see neuro sxs)
anemia with schistocytes, thrombocytopenia & renal dysfunction in the absence of other causes of coagulopathy = HUS
DIC vs HUS: dx DIC low fibrinogen; HUS normal fibrinogen
Most severe bleeding disorder hemophilia A (low VIIIc)
folate def is ______ anemia; erythropoeisis is due to lack of: megaloblastic anemia; lack of methylation
Autosomal Recessive, pain in extremities after exercise, priapism Sickle cell dz
hypochromic microcytic anemias include: Fe def, thalassemia, sideroblastic, anemia of chronic dz
Thalassemia genetics alpha: 2/2 gene deletion; beta: 2/2 point mutation
Microcytosis out of proportion to the anemia = thalassemia
Thalassemia: alpha globin chains 1 chain = Hgb H dz; all 4 chains deleted: hydrops fetalis (stillbirth); silent carrier = 1 gene deleted (nml MCV)
Cooley anemia AKA: beta thalassemia major
beta thalassemia major S/S sx onset 4-6 mos old; growth probs, abnormal facies, fx's, osteopenia, bone deforms, HSM, jaundice
sideroblastic anemia causes myelodysplasia, chronic EtOH, Pb tox
N/N anemia pathophys hepcidin upregulation in response to inflammatory mediators
N/N anemia etiology organ fail d/t systemic dz (renal, endo, thy, liver), or impaired marrow fn (2/2 chronic infxn, aplastic anemia, PRCA)
macro anemia 2/2 folate def: S/S glossitis, no neuro sx
macrocytic anemia 2/2 B12 def S/S glossitis, pale icterus, GI sxs; neuro sxs (posn, vib sense, stocking-glove paresthesia, ataxia)
B12 def causes No. 1 pernicious anemia; veganism, blind loop syndrome, gastric surg, panc insuff, Crohn dz
SCD complications AVN of femoral head; cholelithiasis, splenomeg, Strep pneumo infxn, stroke, priapism, retinopathies, osteomyelitis
Bleeding d/o clin findings: plt vs coag plt: mucosa & skin; petechiae in low plt (NOT plt dysfn); coag: skin & mx; spont hemarthrosis in severe hemophilia
most common cause of abnormal bleeding: thrombocytopenia
Created by: Adam Barnard Adam Barnard