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AntiCancer First Aid
WVSOM -- First Aid -- AntiCancer Drugs
| Question | Answer |
|---|---|
| What is log kill? | fixed percentage that increaes with growth fraction |
| When do you use a cell-cycle nonspecific drug? | Low fixed growth |
| What drug is used to rescue from MTX? | Leucovorin |
| What is MTX MoA | Folic acid analog that inhibits S phase |
| What is MoA of 5-FU | Pyrimidine analog in S phase |
| What is 5-FU used for? | solid tumors and basal cell carcinoma (topically) |
| How do you rescue 5-FU toxicity? | thymidine |
| MoA 5-MP | purine analog in S phase activated by HGPRTase |
| What is the important interaction with 6-MP? | metabolized by xanthine oxidase so increased toxicity with allopurinol |
| If you want to give 6-MP to a patient on allopurinol what can you give instead? | 6-TG |
| MoA dactinomycin | intercalates in DNA |
| when do you give dactinomycin | wilm's tumor, sarcoma, rhabdosarcoma (childhood tumor) |
| Doxorubicin side effect | cardiotoxicity |
| what is the antidote for doxorubicin | dexrazaxane |
| when do you give doxorubicin? | hodgkin's lymphoma |
| MoA doxorubicin | generate free radicals |
| Bleomycin MoA | G2-phase specific by breakign DNA strans with free radicals |
| when do you use bleomycin? | Testicular cancer adn Hodgkin's |
| what is side effect of bleomycin | pulmonary fibrosis |
| What is major side effect of cyclophosphamide | hemorrhagic cystitis prevented by mesna and aggressive hydration |
| Nitrosourea clinical use | brain tumor |
| What is side effect of vinblastine | Blasts Bone marrow |
| What is side effect of vincristine? | neurotoxicity |
| MoA paclitaxel | M phase and hyperstabilizes mitotic spindles so they can't break down |
| MoA vincristine/blastine? | blocks M phase by blocking polymerization of microtubules |
| What is major side effect of Cisplastin? | NAUSEA!!! Nephrotoxicity and acoustic nerve damage |
| What part of the cell do drugs work on if they act in M-phase? | microtubules |
| MoA of tomoxifen | receptor antagonist in breast and bone blocking the binding of estrogen receptor cells |
| What drug also has same MoA as tomoxifen? | raloxifene |
| When is imatinib used? | CML with philadelphia chromosome |
| trastuzumab clinical uses | monoclonal antibody agains HER-2; aka herceptin |
Created by:
Todd Jamrose
on 2010-05-28