Welcome to StudyStack, where users create FlashCards and share them with others. Click on the large flashcard to flip it over. Then click the green, red, or yellow box to move the current card to that box. Below the flashcards are blue buttons for other activities that you can try to study the same information.
Test Android StudyStack App
Please help StudyStack get a grant! Vote here.
or...
Reset Password Free Sign Up

Free flashcards for serious fun studying. Create your own or use sets shared by other students and teachers.


incorrect cards (0)
correct cards (0)
remaining cards (0)
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the Correct box, the DOWN ARROW key to move the card to the Incorrect box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

Correct box contains:
Time elapsed:
Retries:
restart all cards


Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm1Pkin

Pharm1 Pharmacokinetics

QuestionAnswer
What is clearance? The removal of a drug in units of volume/time.
Intensity of effect related... To drug concentration at receptor sites.
Duration of action related to... How long drug conc. at receptor site remains high enough to provide response.
One-compartment model easiest to use, and many drugs follow this scheme. Assumes a single compartment which is in equilibrium which accounts for drug in plasma, and various tissues.
Two (or more) compartment models more difficult to model. Seen when drug moves into tissues and is handled at different rates than central plasma compartment.
Two compartment model... Involves both distributive and elimination phases normally.I
Describe log plot of two compartment model: Log plot does not give a single straight line, but instead shows two phases.
What is zero-order kinetics? The rate is independent of the concentration.
What happens if a process (ex.- elimination) is dependent on a carrier or enzyme that may become saturated? Rate now no longer dependant on concentration, but instead becomes constant, at least until concentration falls below saturation. (Zero-order kinetics)
Bioavailability: Percentage of a drug or drug product that enters the general systemic circulation. Includes not only amount entering body, but also rate of entry.
What is the volume of distribution? The volume of distribution, Vd, is the apparent or “virtual” volume into which a drug distributes.
Can Vd be larger than the total plasma volume in the body? heparin = 5 liters (plasma only) chlordiazepoxide = 28 liters (extracellular water) imipramine = 1600 liters (highly lipid soluble)
Knowledge of the Vd is also important in estimating the... Loading dose.
About how many half-lives to reach steady-state? Five.
Drugs with a t1/2 less than 6 hours require a <blank> to use them in repeated doses. Very wide therapeutic window.
Drugs with narrow therapeutic windows should be given by... Continuous infusion.
First pass may be saturable, and like all liver metabolism may increase due to... Enzyme induction.
High Extraction Ratio: ClH controlled by blood flow rate, Strong first-pass effect, Plasma protein binding may facilitate clearance
Low Extraction Ratio: ClH controlled by intrinsic clearance, Biotransformation limited by diffusion, Plasma protein binding reduces clearance, Sensitive to enzyme inhibition and induction
Rate of renal excretion = Rate of filtration + Rate of secretion – Rate of reabsorption
For Biliary Excretion: ClB = (Conc. in bile / Conc. In plasma) Bile flow
What is normal bile flow? Bile flow normally 0.5 – 0.8 ml/min.
Created by: Chelsea Leigh Jones Chelsea Leigh Jones on 2010-05-01



bad sites Copyright ©2001-2014  StudyStack LLC   All rights reserved.