Save
Busy. Please wait.
Log in with Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm1Pkin

Pharm1 Pharmacokinetics

QuestionAnswer
What is clearance? The removal of a drug in units of volume/time.
Intensity of effect related... To drug concentration at receptor sites.
Duration of action related to... How long drug conc. at receptor site remains high enough to provide response.
One-compartment model easiest to use, and many drugs follow this scheme. Assumes a single compartment which is in equilibrium which accounts for drug in plasma, and various tissues.
Two (or more) compartment models more difficult to model. Seen when drug moves into tissues and is handled at different rates than central plasma compartment.
Two compartment model... Involves both distributive and elimination phases normally.I
Describe log plot of two compartment model: Log plot does not give a single straight line, but instead shows two phases.
What is zero-order kinetics? The rate is independent of the concentration.
What happens if a process (ex.- elimination) is dependent on a carrier or enzyme that may become saturated? Rate now no longer dependant on concentration, but instead becomes constant, at least until concentration falls below saturation. (Zero-order kinetics)
Bioavailability: Percentage of a drug or drug product that enters the general systemic circulation. Includes not only amount entering body, but also rate of entry.
What is the volume of distribution? The volume of distribution, Vd, is the apparent or “virtual” volume into which a drug distributes.
Can Vd be larger than the total plasma volume in the body? heparin = 5 liters (plasma only) chlordiazepoxide = 28 liters (extracellular water) imipramine = 1600 liters (highly lipid soluble)
Knowledge of the Vd is also important in estimating the... Loading dose.
About how many half-lives to reach steady-state? Five.
Drugs with a t1/2 less than 6 hours require a <blank> to use them in repeated doses. Very wide therapeutic window.
Drugs with narrow therapeutic windows should be given by... Continuous infusion.
First pass may be saturable, and like all liver metabolism may increase due to... Enzyme induction.
High Extraction Ratio: ClH controlled by blood flow rate, Strong first-pass effect, Plasma protein binding may facilitate clearance
Low Extraction Ratio: ClH controlled by intrinsic clearance, Biotransformation limited by diffusion, Plasma protein binding reduces clearance, Sensitive to enzyme inhibition and induction
Rate of renal excretion = Rate of filtration + Rate of secretion – Rate of reabsorption
For Biliary Excretion: ClB = (Conc. in bile / Conc. In plasma) Bile flow
What is normal bile flow? Bile flow normally 0.5 – 0.8 ml/min.
Created by: 1592042303
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards