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UAMS Teratogens

From Embryology Chapter 20

Sequence A pattern of multiple anomalies derived from a single known or presumed structural defect or mechanical factor.
Deformation A mechanical external forces which acts on the embryo.
Diabetes Mellitus Sirenomelia, Macrosomia, TGA, VSD, TOF, Ebstein's Anomaly, PTA,
Diethystilbestrol Adenocarcinomas of the vagina in later life.
Thalidomide Shortened Limbs, Now useful in HIV, Meromelia, Amelia.
Dysplasia Abnormal cell organization
Isotretinoia, Retinoic Acid, Vitamin A Neuropsychological Impairment, NTD
Varicella Skin Scarring, Muscle Atrophy, Hypoplasia of Limbs
PKU Mental Retardation, IUGR, HLHS, VSD
Disruptions Extrinsic breakdown of, or an interference with, an originally normal developmental process
Phenytoin (Dilantin, Novophenytoin) Fetal Hydantoin Syndrome, IUGR, Microcephaly, Mental Retardation
Trimethadone Pre and Post natal developmental delay, V-shaped eyebrows - Is an Anticonvulsants
Warfarin (Coumadin) Stippled Epiphyses. Use Heparin
Rubella Cataracts, Cardiac, Deafness. Pulmonic Stenosis, PDA.
Lithium Carbonate Epstein's anomaly
Malformations Intrinsically abnormal development process
Cytomegalovirus Brain Calcifications, Deafness, Cerebral Palsy
FAS Smooth Philtrum, Thin Upperlip, Narrow Eyes, VSD
Polytopic field defect Pattern of anomalies derived from the disturbance of a single development field
Valporic Acid NTD
Syndrome A pattern of multiple anomalies thought to be pathogenically related. CHARGE, VACTERL/VATER
Aminopterin, Methotrexate NTD, Folic Acid Antagonist, CNS Malformation.
Association A nonrandom occurrence in 2 or more individuals of multiple anomalies not known to be an other.
Tetracycline Teeth Anomalies
Toxoplasmosis gondii Eyes, Ears, Cerebral Calcifications
Streptomycin and Dihydrostrptomycin Deafness
Androgens, Progestogen, Progestins, ethisterone, norethisterone Masculinization of female gonads.
Created by: btkosewski