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muscle tango2142

Muscle Stimulation
1. Impulse (Wave of depolarization) travels down the axon (pumps shut down).
2. Voltage regulated Ca2+ channels open in axon terminal.
3. Ca2+ diffuses onto axon terminal.
4. Ca2+ binds to vesicles containing neurotransmitter (Ach).
5. Vesicles move to and fuse with cell membrane.
6. Ach is released by exocytosis (active transport requires energy).
7. Ach binds to chemically regulated Na+ channels of the motor end plate->channels open and allow Na+ to diffuse into muscle fiber.
8. Once the motor-end plate has depolarized ->1st voltage regulated Na+ channels open in sarcolemma->wave of depolarization (action potential).
9. Action potential spreads along sarcolemma, down t-tubules-along the SR->Ca2+ diffuses out of SR->cytoplasm(sarcoplasm).
10. Find
11. Troponin/tropomysin move and expose myosin binding site. (ATP has bound to the myosin head and ATP has splint ->Energy released->energizes myosin head.)
12. Energized myosin head binds to actin.
13. Myosin head bends and pulls actin past it. (ADP +Pi released)
14. ATP binds to myosin head causing the myosin head to detach from actin.
15. ATPase splits ATP->ADP+Pi; Energy that is released energizes myosin head so it can now bind to another myosin binding site on actin and cause further sliding.
16. Achestrase breaks down Ach->detaches from chemically regulated Na+ channels->close.
17. Voltage regulated Na+ channels close wave of Na+ channels closing.
18. K+ channels open ->K+ diffuses from in->out. (Purpose: restore charge difference.)
19. K+ channels close.
20. NaK pumps activated ions diffuse between inside and out.
Wave of repolarization spreads along sarcolemma-> down t-tubules->along SR->SR Ca2+ pumps activated-ca2+back into SRfilaments back to resting state.
This is an ALL or NONE process. A muscle fiber will contract or not at all-No partial contraction.
Created by: Tango2142