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adrenal phys

physiology of adrenals

glomerulosa aldosterone
fasciculata cortisol
reticularis androgens (DHEA)
21 carbon steriods progesterone, deoxycorticosterone, aldosterone, cortisol
21 carbon steriods progesteron is the precursor for all 21 carbon steroids
21 carbon steriods hydroxylation at C21 gives deoxycorticosterone
21 carbon steriods hydroxylation at C17 produces glucocorticoids
19 carbon steriods have androgenic activity
18 carbon steriods have estrogenic activity
glucocorticoids oscillates with circadian rythem, highest at 8AM and lowest at 12PM
ACTH stimulates secretion in all zones fo the adrenal by stimulating cholesterol desmolase
ACTH up regulates it's own receptor
cortisol inhibits the secretion of CRH by negative feedback
mineralocorticoid increases renal sodium reabsorption, potassium secreation, and hydrogen secretion
aldosterone secretion is regulated by the renin-angiotension system, hyperkalemia increases aldosterone secretion
glucocorticoids stimulates gluconeogenisis by; increasing protein catabolism, decreasing glucose utilization, increases lipolysis
glucocorticoids anti-inflammatory effects are induces the synthesis of lipocortin which inhibits phospholipase A2), inhibits production of interleukin-2, inhibits release of histamine and serotonin
glucocorticoids suppress the immune response by inhibiting the production of IL-2
glucocorticoids mantains vascular response to catecholamines by up regulating alpha 1 receptors
Created by: swohlers