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WVSOM immuno #4

WVSOM immune system #4 immuno

What are the organs of the immune system? thymus, bone marrow, spleen, lymphnode, other lymphoid tissue
What are the cells of the immune system? lymphocytes, antigen-presenting cells, inflammatory cells
What are the soluble factors of the immune system? Antibody, cytokines, complement
What is the cell surface proteins? MHC proteins, cell adhesion molecules, receptors, CD proteins (e.g,CD4, CD8)
What is the major role of Primary immune organ? place where phagocytes, Maturation production
What are some primary lymphoid organs? thymus, bone marrow
What are the secondary lymphoid organs and tissues? tonsils and adenoids, bronchus associated lymph tissue, lymph nodes, bone marrow, spleen, lymphoid nodules, mesenteric lymph nodes, peyer’s patch, urogenital lymphoid tissue
Does each factor active the same transcription factor causing similar responses? NO, Different factors activate different transcription factors causing different responses
What two types of progenetor cells does a pluripotent stem cell make? lymphoid and myeloid
What does the lymphoid progenitor differentiate into? B and T lymphocytes and natural killer cells
What does Myeloid progenitor cells differentiate into? Erythroid CFU, Megakaryocyte, Basophile CFU, Eosinophil CFU, and granulocyte-monocyte CFU
What does Erythroid CFU differentiate into? erythrocytes
What does Megakaryocytes make? platelets
What does Granulocytes make? neutrophils
Where is the primary site for B lymphocyte development and hematopoesis? Bone marrow
The growth factor stem cell factor (SCF) affects what cells? All hematopoietic cells
The growth factor IL-3 (multi-CSF) affects what cells? Granulocytes, monocytes, RBC
The growth factor GM-CSF affects what cells? granullocytes, monocytes, dendritic cells
The growth factor G-CSF affects what cells? neutrophils (PMN)
The growth factor Erythropoietin affects what cells? Erythrocytes
What is the Primary purpose of the thymus gland? maturation and education of T cells
What is happening In the Education process of the thymus gland? tells them to develop and eliminate the T-cells that may be auto-reactive so they won’t attack us, Make sure that the T cell only recognize the antigen
Explain the adult thymus: You will still find some activity in the adult thymus but for the most part there is a lot of atrophy
Is the spleen a primary or secondary lymphoid organ? secondary
What do lymphoid cells in the white pulp of the spleen surround? arteries
Spleen what does it do? Primary function is to filter blood and sample the blood for pathogens and present antigens
What is the purpose of lymphoid tissue? will sample the organisms that may be in the blood to determine the response, sample and induce immune response
What is the major complication for spleenectomy? infections
Is the spleen important in fighting infection? very important as anti infection mechanism
What are the Collection points among the lymphatic organs? tonsils, thymus, lymph nodes, lymphatic vessels, liver, spleen, peyer’s patch on small intestine, appendix, and bone marrow
Where is the lymph is filtered and sampled for pathogens? lymph nodes
Is the lymph node an Antigen presenting cells as well? yes
What type of cells are primarily in the Cortex of the lymph node? B cell cells
Under the cortex is the paracortex in the lymph node is where most of the what hang out? T cells hang out and antigen presenting cells
Under the paracortex of the lymph node you find the medulla area where what happens? lymph will come in and exit the lymph node
Are the areas of the lymph node physically separated? no they interact with each other so the B cells and T cells need to inter act to activate each other.
What does the primary follicles look like in the lymph node? Primary are quiet not been activated and they stain dark
What does the Secondary follicles look like in the lymph node? have a lot more going on they stain lighter
Where do you find Mucosa-associated lymphoid tissues (MALT)? Anywhere you will have an opening you have mucous membrane and you have lymphoid tissue, eg. Respiratory, GI, urogenital
What is the function of the appendix? You really don’t know the function of the appendix but seems to be responding to antigens because they have a lot of lymphoid cells in it
What do B lymphocytes differentiate into? plasma cells that make antibody
What are T cells? the regulators of the immune system they have helper and killer function
What are the two major classes of lymphocytes? B and T lymphocytes
Natural killer cells are not antigen specific but they are another form of what? lymphocytes the major function is to kill virus infected cells and tumor cells
What is the function of natural killer T cell (NKT)? recognize glycolipids
What are Antigen presenting cells? cells that present antigen
Does T-cells have to have antigenic peptides presented before they are activated? yes
Lymphocytes of the immune system have to recognize antigen on the surface of the cell before what can happen? activation of the immune response
Will T lymphocyte recognize some antigen on its own surface? No only on the surface of another cell
What is included in APC? dendritic cells, macrophages, and B-lymphocytes
What is the important purpose of dendritic cells? its the most important APC for activating T cells
List some inflammatory cells? neutrophils, eosiniophils, basophils, mast cells, epithelial cells, endothelial cells, platelets
What are cell surface molecules? cell adhesion molecules, membrane receptors, major histocompatibility complex (MHC) proteins, and CD molecules
How many different types of receptors are there? one for every type of cell, one for B,T,ect.
When was MHC proteins first discovered? when they started doing organ transplants, the host body would reject the donor organ due to the difference in MHC proteins
Why does MHC activate the immune response? These are involved in activating the t cells, they differ from person to person, MHC proteins have a little pocket with proteins in it that the T cells recognize, this will activate the immune response
Where is CD2 expressed and what is its function? T cells, NK; adhesion
Where is CD3 expressed and what is its function? T cells; activation
Where is CD4 expressed and what is its function? helper T cells; adhesion
Where is CD8 expressed and what is its function? killer T cells; activation
Where is CD21 expressed and what is its function? B cells; activation
Where is CD34 expressed and what is its function? stem cells; adhesion
Where is CD40 expressed and what is its function? B cells; activation
Where is CD95 expressed and what is its function? many cells; apoptosis
Are there many cytokines and What are cytokines? Many different types of cytokines they are the communication molecules that induce stuff on other cells
List some soluble immunologic factors: immunoglobulin (antibody), complement, cytokines
What produces antibodies and what is their function? immunoglobulins are produced by plasma cells and they mediate antigen recognition and immune effector functions
What are the functions of the immune effector? antigen binding, neutralization of microbial toxins, inhibiting attachment of microbes, opsonization, activate complement, and protection of developing fetus
Created by: hagerman