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DM Endo Adrenal

Endocrinology

QuestionAnswer
Cortisol main glucocorticoid hormone produced by the adrenal cortex
What kind of secretion dose cortisol have? Diurnal. Highest in the morning, lowest in the evening
Cortisol functions increases glucose and gluconeogenesis.
Too high cortisol turns off acth production
Low cortisol ACTH ramps up
What affects serum cortisol levels? Circadian rhythm, stres and glucocortioid use
How can you measure cortisol levels? 24 hour urine cortisol; specifically in screening for Cushing's syndrome. Salivary cortisol can also be obtained.
24 hour urine cortisol Collect 5ml from a 24 hour-collection within 4 hours of completion
ACTH is also known as Corticotropin
High ACTH levels indicate primary adrenal insufficiency (Addison's disease)
Low ACTH levels indicate secondary adrenal insufficiency
Increased ACTH present in come back to
Decreased ACTH present in come back to
Normal responsee to dexamethasone Suppression of cortisol secretion
Name the indirect way to measure plasma glucocorticoids 17-OCHS levels; lab limitations caused by drugs, estrogens, urine glucose
What is the primary method of evaluation of endocrine issues? Labs (imaging is not first)
What imaging study is used to look for calcification on the adrenal cortex that may be due to a TB infection? X-ray
What imaging method is used to evaluate the size and shape of the adrenal glands and pituitary? CT or MRI
Aldosterone production is regulated by the kidney renin-aldosterone system
One of the few causes of HTN that is potentially curable Primary Hyperaldosteronism
Created by: ltm12
 

 



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