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Why is Acetaminophen not considered an NSAID? Lack ant-inflammatory & antcoagulant properties
NSAID's with a high risk for hypertension? Feldene, Indocin, Motrin
NSAID's with highest risk for GI problems? Feldene, Indocin, Meclomen, Nalfon, Ansaid
Best representative of an NSAID... Aspirin
NSAID's inhibit biosynthesis of what? Prostaglandins
Increase sensitivity of pain receptors to mechanical pressure and the effects of other pain-producing substances? Prostaglandins
"Normal" constituent in certain cells ex: stomach mucosa, kidneys..? COX-1
"Emergency" enzyme that synthesizes prostaglandins in response to cell injury? COX-2
What accounts for the primary side effects of NSAID's? Inhibit the COX-1 enzyme which decreases the production of beneficial and protective prostaglandins
Factors that increase risk of serious GI damage...? advanced age, hx of ulcers, use of multiple NSAIDs, use of high dose NSAID, use of other agents
What type of drug is more likely to inhibit production of the pathological prostaglandins, while sparing the production of beneficial ones? COX-2
What type of drugs can cause renal and hepatic problems by inhibiting the synthesis of prostaglandins that maintain blood flow and function? Aspirin-like
COX-2 drugs have increased risk of...? Clots in the coronary and carotid arteries
Often the first drug used to control pain in early stages of osteoarthritis and other musculoskeletal conditions? Acetaminophen
What drug preferentially inhibits CNS prostaglandin production? Acetaminophen
Pre-existing liver disease and chronic alcohol abusers are susceptible to liver damage cause by high doses of what? Acetaminophen
Created by: txst spr 2009