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RS Microbiology

Respiratory System Microbiology - Bacteriology-Atypical Pneumonia

Atypical pneumonia is caused by: Mycoplasma-Chlamydia-Legionella Gram -ve bacteria Few LPS
Symptoms of atypical pneumonia: Dry cough & mild fever often persist for weeks
What is the smallest known bacteria? M. pneumonia
Cell wall of M. pneumonia: Lack true cell wall
Mycoplasma pneumoniae causes Cause serious respiratory disease and death
How is M. pneumoniae spread? Droplet infections
Symptoms of M. pneumonia: Low fever & dry cough symptoms Eventually, Mild rashes, neurological syndromes Acute/ Subacute Pharyngitis & Bronchitis -children, young adults
Lab diagnosis of M. pneumoniae: Special culture medium Mycoplasma specific DNA by PCR Sputum,Pleural fluid,Blood Serological Cold-Agglutination Test: Increased Ab titers after 4-weeks
Treatment of M. pneumoniae: Levofloxacin, moxifloxacin, Macrolides/ Azithromycin NO vaccine
Characteristics of Chlamydia: Obligate intracellular bacteria causing intracytoplasmic inclusions Rapidly killed outside body tissues, Dryness & high temperature
Life cycle of Chlamydia: Infectious elementary bodies attached to lung mucosa and promoting its entry into lung tissues Reticulate bodies developed as inclusion bodies in cytoplasm phagosomes & released new Infectious elementary bodies
Chlamydia trachomatis is a common cause of: Sexually transmitted disease (STD) Nonspecific urethritis Transmitted from mother to newborn babies Severe pneumonia Eye infection Conjunctivitis & Trachoma
Chlamydia pneumonia is related only to; The respiratory tract
C. Pneumonia is transmitted by: Resp. droplets
Symptoms of C. pneumonia: Mild respiratory symptoms, dry irritating prolonged cough, nasal congestion with/without fever No blood sepsis Infection in adults often asymptomatic, mild, may include sore throat, headache, fever, dry cough. Rare Acute infection
Diagnosis of C. pneumonia: Sputum, throat-nasal swabs, MaCoy Cell Culture, ELISA Specific antibodies, PCR
Treatment of C. pneumonia by: Macrolides, Tetracyclines, levofloxacin, moxifloxacin NO Vaccine
Characteristics of Legionella: Flagella Widely spread in cold natural water bodies and wet soil Facultative Anaerobes Grow in Cold/Hot water(0- 80C) Transmitted by inhalation of contaminated water drops Cause single cases /more outbreak of disease
Incubation period of Legionella: 2-10 days
Symptoms of Legionella: High fever Nonproductive dry cough Mild fever at start Blood sepsis Shortness of breath Chest & Muscles pain Joint pain Diarrhea Renal failure
Risk factors of L. pneumonia: Heavy cigarette smoking Old age Underlying diseases such as renal disease, cancer, diabetes, chronic pulmonary obstructions, suppressed immune systems Corticosteroid therapy High death rate in patients with presence lung obstructions
Diagnosis of L. pneumonia: Special culture media.. blood/urine specimen for detection Specific antibodies or Antigens by PCR, or ELlSA
Treatment of L. pneumonia: Macrolides/azithromycin, levofloxacin, moxifloxacin NO Vaccine
Created by: Ulaisl