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General 3
Q bank: Randomly Generated 3
| Question | Answer |
|---|---|
| Alternating constricion and dilation of intrahepatic bile ducts in a UC patient causing jaundice. | Primary sclerosing cholangitis; associated with UC |
| What is the virus associated with nasopharyngeal carcinoma? | EBV; also malignant soft-tissue mass of the jaw |
| What virus is associated with adult T-cell leukemia? | Human T-lymphocyte virus (HTLV-1) |
| What virus is associated with cutaneous and mucous-membrane plaque-like violaceous lesions? | Kaposi sarcoma, associated with HHV 8 |
| This drug prevents the binding of aminoacyl-tRNA to ribosomes. | Tetracycline |
| This type of amyloid is seen in primary amyloidosis and most frequently deposits in the heart. | Transthyretin |
| This type of amyloid is associated with secondary amyloidosis (autoimmune, chronic infection) and deposition occurs mostly in kidney, spleen and liver. | Amyloid-associated protein |
| This type of amyloid is seen in primary amyloidosis with systemic deposition. | Amyloid light chain |
| This type of amyloid is seen with long-term hemodialysis with musculoskeletal deposition. | Beta-2 microglobulin |
| 7 yro girl develops behavior changes, and school perforrmance detiorates. Months later develops seizures, ataxia, and focal neurologic symptoms. Eventually quadriparetic, spastic, and unresponsive. Death within a year. What virus at age 1 caused this? | Rubeola; patient has subacute sclerosing panencephalitis |
| What type of hypersensitivity reaction is the tuberculin skin test? | Delayed-type (type IV) cell mediated immune response involving CD4 TH1 activation of macrophages |
| What type of hypersensitivity is an Arthus reaction? | Immune complex (type III) involving antibody, antigen, and complement activation |
| 60 yro man presents with bacterial meningitis, what are the most likely agents? | S pneumoniae, Listeria, N meningitidis |
| What test is used to distinguish between heretiable and sporadic retinoblastoma? | PCR; in heritable cases, any cell in the body will show altered chromosome (deletion or translocation), in sporadic caases only the tumor will show mutation |
| Patient has CN function with the exception of the ability to look up. Diagnosis? | Pinealoma; compresses vertical gaze center in the tectum of the midbrain |
| Where are the estrogen, progesterone, and HER2 EGF receptors located? | Estrogen and progesterone are located in the nucleus, HER-2, a growth factor, likely has it's receptor on the cell membrane |
| What stain is used to identify hairy cell leukemia? | tartrate-resistant acid phosphatase (TRAP) |
| Bilateral bruits of the renal arteries with a beaded pattern on angiography. If these vessels were surgically resect, what would be apparent? | Fibromuscular dysplasia |
| The median nerve is subject to entrapment neuropathy when it passes between the two heads of what muscle? | Pronator teres |
| What causes the sensation of pain felt in carpal tunnel syndrome? | Compression of the median nerve |
| What is angiostatin? | anti-angiogenic factor expressed by tumors that tends to inhibit angiogenesis |
| What would be the difference in the appearance of chromatin of prostatic cells in castration versus trauma to the prostate? | Castration (removal of androgenic stimuli) induces apoptosis in prostate cells. Chromatin would exhibit peripheral aggregation; Trauma would cause chromatin to become more pale (karyolysis) and form irregular clumps |
| 65 yro man with ankle edema, and inflammation of the skin near both ankles. Skin exhibits edema, mild scaling, and brown discoloration. On one ankle, a 1 cm ulcerated area seen in erythematous area. Diagnosis? | Stasis dermatitis from venous stasis |
| These viruses are segmented, and thus are capable of genetic drift. | Influenzae of orthomyxoviridae; Rotavirus and Reovirus of reoviridae; Ortho is single stranded, reo is double stranded (the only RNA viral family that is) |
| These cells in the semineferous tubule have very pale nucleus and darkly staining nucleoli. | Sertoli cells, establish blood-testis barrier via tight junctions (note they do not protect the spermatogonia which lie directly on BM) |
| What are the tumors related to von-Hippel Lindau disease and what chromosome is the deletion on? | Hemangioblastomas of the retina, cerebellum, and/or medulla. Roughly half will develop bilateral renal-cell carcinoma; VHL gene deletion on chromosome 3 |
| A patient with truncus arteriosus will also have what cardiac abnormality? | VSD |
| This is a mesenteric membrane between the liver and the anterior abdominal wall. | Falciform ligament |
| Chronic poisoning with this substance causes CNS atrophy, gingivitis, gastritis, and renal tubular changes. | Chronic mercury poisoning |
| This drug causes both metabolic acidosis and respiratory alkalosis. | Salicylates |
| Patients with myasthenia gravis have autoantibodies directed against what cellular component? | Nicotinic acetylcholine receptors at motor endplates (ligand gated ion channels) |
| Patients with Lamber-Eaton syndrome have autoantibodies directed against what cellular components? | voltage-gated calcium channels |
| Proliferative synovitis with many lymphocytes, macrophages, and plasma cells. Diagnosis? | Rheumatoid arthritis |
| Joints with excessive cartilage loss and reactive bone formation. | Osteoarthritis |
| This macrolide inhibits calcineurin-mediated transcription of IL-2, and is used to prevent cytotoxic T cell activation in liver transplant patients with adverse corticosteroid reactions. | Tacrolimus |
| This drug used in renal transplanation inhibits T-cell proliferation by binding serine threonine kinase (mTOR) necessary for cell-cycle progression. | Sirolimus |
| This type of leukemia is related to DIC upon implementation of antineoplastic agents. | Promyelocytic (M3) AML; release of Auer rod granules triggers DIC |
| What nerves are responsible for adduction and extension of the thumb? | Ulnar nerve (adductor pollicis); Radial nerve (extensor pollicis longus and brevis) |
| Malignant mesenchymal tumor that develops in the pelvis, shoulders, or ribs which appears slightly basophilic on H&E. | Chondrosarcoma |
| Benign bone-forming tumor composed of well-differentiated bone trabeculae arranged haphazardly. | Osteoid osteoma or osteoblastoma (larger and found in vertebrae) |
| Rhabdomyoma are related to what disorder? | Tuberous sclerosis |
| Imagined bodily defect or exaggerated distortion of minimal or minor defect with impairment of social, occupational, or other are of functioning. Diagnosis? | Body dysmorphic disorder |
| Unconscious drive for medical attention, often accompanying somatoform pain disorder. | Secondary gain; somatoform pain is pain unsupported by any physiologic process |
Created by:
rahjohnson
on 2009-02-12