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DM Meds

Secretagogues MOA stimulates the pancreas to produce more insulin
Sulfonylureas glyburide: Low BG glipizide: weight gain glimepiride
Meglitinides repaglinide: low BG nateglinide: headaches
Biguanides MOA decrease hepatic glucose production
Biguinides meds Metformin: N/D, metallic taste, lactic acidosis Combo pills can cause above + hypoglycemia
Alpha-glucosidase inhibitors MOA slows carbohydrate absorption in intestines
alpha-glucosidase inhibitors meds acarbose: N/D, gas Miglitol
TZDs MOA improves peripheral insulin sensitivity
TZDs meds pioglitazone: bladder CA, CHF, liver rosiglitazone: increase risk of MI and fracture
Incretins (DPP4-inhibitors) MOA: protects GLP1 by stopping breakdown of internal GLP1. increases insulin release and reduces hepatic glucose release. Sitagliptin, linagliptin, saxagliptin, alogliptin NO HYPOGLYCEMIA!
Incretins (GLP-1 receptor agonists) MOA: stimulates insulin release when BG increasing, regulates food release, slows hepatic glucose release bydureon, exenatide, liraglutine SE: increase satiety, weight loss, nasea (DO NOT use if thyroid CA personal or family hx)
sodium glucose co-transporter-2 (SLGT2) MOA: helps kidneys dump glucose canagliflozin, dapagliflozin SE: UTI/yeast infx possible **used w/ all meds
rapid-acting (meal) insulins Humalog, Novolog, Apidra Regular: Humulin R, Novolin R
intermediate-acting (basil) insulins NPH: Humulin N, Novolin N Lente: Novolin L
long-acting (basal) insulins Lantus (22+ hrs) Levemir (16-24hrs)
Created by: rjerome09