Busy. Please wait.

Forgot Password?

Don't have an account?  Sign up 

show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.

Already a StudyStack user? Log In

Reset Password
Enter the email address associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know (0)
Know (0)
remaining cards (0)
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how


Where both T and B lymphocytes originate from ? * bone marrow
Lymphoid Neoplasms overview ? * Tumors of B-cell, T-cell and NK-cell origin ..... * Common causes: Genetic factors, environmental factors, viruses, smoking, and radiation/chemo
Leukemia = ? * bone marrow Dx made by sampling bd
Lymphoma = ? * Dx made by sampling a lymph node.... * Le and Ly can turn in to each other, it basically depends where the Dx sample was taken
Cx Features of both = ? * malaise and fatique
How to Dx ? * Biopsy of lymph node/BM biopsy, flow cytometry, cytogenetics and IHC necessary for diagnosis
Acute Lymphoblastic Leukemia/Lymphoma (ALL) cells involved ? * precursor T and B Cells
Childhood ALL = ? * B- ALL, but adults can have this too
ALL morpho ? * hypercellular marrow where lymphoblasts keep proliferating .... * see finely stippled chromatin
ALL IHC test ? * myeloperoxidase negative and PAS+
ALL immunophenotype ? * TdT+ with B-cells with CD19, CD10, PAX5
ALL chromosomes ? * translocations of 12;21
ALL prognosis ? * 75-85 % curable when of the B cell type and Dx between 2-10 y/o, and when there is no CNS involvement
Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) basics ? * same thing, just one was Dx from lymph nodes and the other by blood... * usu in older ppl > 55 and see SUPER high WBC counts 100,000-300,000
Cells in CLL/SLL we see ? * smudge cells in peripheral smear
CLL/SLL immunophenotypes and chromosomes? * CD23, CD5, surface Immunoglobulin + for both T and B cell markers ... * see trisomy 12q
CLL/SLL Cx and prognosis ? * can progress to prolymphocytic leukemia or diffuse large B-cell lymphoma (Richter syndrome)... * survive for extended periods of time and if ZAP-70 is expressed, there is a poor pronosis
Follicular Lymphoma basics ? * arise from Germinal Center B cells, and forms follicles... * Cells we see: Centrocytes and Centroblasts with Spleen white pulp and hepatic portal triads involved
Immunophenotype, Molecular and Cx prognosis of Follicular Lymphoma ? * + BCL2..... * translocation of 14;18 chromosome.... * Clinical – histologic transformation to diffuse large B-cell lymphoma with less than 1 year survival after this
Diffuse Large B-Cell Lymphoma immunophenotype, molecular, and Cx outcomes ? * Immunophenotype – CD19, CD20 .... * Molecular – Dysregulation of BCL6 --> normally silences p53 expression ... * Clinical – rapid course; rapidly/aggressive enlarging mass – nodal or extranodal; rarely leukemic/found in the blood
Burkitt Lymphoma cells we see ? * benign macrophages with nuclear remnants of numerous apoptotic cells --> starry sky pattern... * In Bone Marrow – cells have royal blue cytoplasm and clear cytoplasmic vacuoles
Immunophenotype, Molecular and Cx prognosis of Burkitts Lymphoma ? * Immunophenotype – surface IgM, CD19, CD20, CD10, BCL6; Almost never have BCL2 .... * Molecular 3 translocation possibilities 8;14, 8;2, 8;22.... *Prognosis is aggressive, but respond very well
Mantle Cell Lymphoma basics ? * in 5-6 decades and is very rare
Mantle Cell Lymphoma immunophenotype and Cx ? * Cyclin D1 and NO CD23.... * Molecular – t(11;14) .... * it is not curable
Marginal Zone Lymphoma basics ? * causes MALTomas and arrise to to chronic inflammation in such disorders as Sjogren, Hashimoto, H. pylori
Marginal Zone Lymphoma molecular ? * Up regulate expression & function of BCL10 and MALT1
Hairy Cell Leukemia immunophenotype, molecular, and prognosis ? * lymphocytes with fine hair-like projections.... * Immunophenotype - CD11c, CD25, CD103..... * prognosis is excellent
Hairy Cell Leukemia signs ? * dry tap when trying to get samples to Dx
Peripheral T-Cell Lymphoma, Unspecified basics ? * Clinical – generalized lymphadenopathy; eosinophilia, pruritis, fever & weight loss Worse prognosis than aggressive mature B-cell neoplasms .... * rule out everything else first
Anaplastic Large Cell Lymphoma (ALK Positive) basics ? * large anaplastic cells with horseshoe-shaped nuclei .... * rearrangement of ALK gene on chromo 2p23 , which trigger JAK/STAT
Adult T-Cell Leukemia/Lymphoma basics ? * Adults infected with HTLV-1 (Human T-cell Leukemia retrovirus type 1).... * multilobated nuclei (clover leaf or flower cells)..... * see mature T-cell markers and CD4 only (NOT CD8)... * can see skin lesions/scabbing look
Mycosis Fungoides/Sezary Syndrome basics ? * Cutaneous T-Cell Lymphoma (CTCL) – presents in the skin and may evolve into generalized lymphoma.... * Stages: patches, plaques, nodules.... * see Sezary cells and Pautrier microabscesses.... * see CLA, CCR4 and CCR10.... * epidermotropism in skin
Large Granular Lymphocytic Leukemia basics ? * T-cell and NK-cell variants.... * abundant blue cytoplasm containing a few coarse azurophilic granules (red)(called LGLs)... ** See CD56 **..... * course is dependent on degree of cytopenias
Extranodal NK/T-Cell Lymphoma basics ? * Destructive nasopharyngeal mass but can be in testis and skin.... * get ischemic necrosis... * see EBV episomes in tumor cells
Created by: thamrick800