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cytoskeletal protein

Hansen's large list of proteins associated with the cytoskeleton

Formin activated by Rho; initiates actin filament formation/nucleation (rate limiting step)
Arp 2/3 activated by WASP; initiates actin branching - important in forming new actin branches at leading edge during cell migration
ADF/cofilin depolymerizes actin and sequesters it; also can sever actin filaments
Spectrin binds actin to plasma membrane proteins in RBC's and thus cross-links actin
Fimbrin actin cross-linking protein that creates closely spaced actin bundles - seen microvilli
α-actinin actin cross-linking protein that creates widely spaced actin bundles - seen contractile bundles and stress fibers
Focal adhesion complex of proteins that attach plasma membrane to stress fibers: ECM-Integrin-Talin-Vinculin-Actin (stress fibers)
Myosin II fast, (+) oriented, actin, used in mm contractions and cell migration
Myosin I Fast, (+) oriented, actin, used in vesicle/cargo transport and connecting actin to plasma membrane in microvilli
Myosin V fast, (+) oriented, actin, used to transport organelles and IFs
CLASP stops microtubes from shrinking
Dyenin Fast, (-) oriented, MT
Kinesin Slow, (+) oriented, MT
Nebulin ensures correct length of actin in sarcomere
Titin gives resting tensile strength to myosin in sarcomere
Calcium/Calmodulin/MCLK complex phosphorolates mysoin in smooth muscle to cause actin/myosin contraction
Created by: c.phill