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Ergot Alkaloids
USMLE Step 1
Drugs | MOA & ADRs |
---|---|
Ergotamine | MOA: 5-HT 2 antagonist autacoid (local hormones), drug of choice for moderate to severe migraines, best if used in the prodromal phase (just beginning); ADRs: don't use in pregnancy, peripheral vascular disease & CAD, causes n/d & severe vasospasms |
Methysergide | MOA: 5-HT2 antagonist autocoid (local hormone) used in prevention of migraine, usually given during prodrome thus only prophylactic, not intended for use during attack; ADRs: nausea, diarrhea & severe vasospasms |
Bromocriptine | MOA: inhibits prolactin release used for hyperprolactinemia (pituitary adenoma) & infertility |
Sumatriptan | MOA: 5-HT 1 agonist, more powerful than the ergot alkaloids, useful in prevention and treatment of ongoing migraine |
Cyproheptadine | MOA: block 5-HT2 receptors that used in the prevention of migraines |
Odansetron | MOA: 5-HT3 antagonist used as a powerful anti-emetic |
Granisetron | MOA: 5-HT3 antagonist used as a powerful anti-emetic |
Metoclopramide | MOA: 5-HT4 agonist used as an anti-emetic causing increased GI motility |
Buspirone | MOA: 5-HT1 agonist used for anxiolysis |