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Onco Rx by Action
Cancer Drugs and their specific mechanisms of action
| Category | Mechanism of Action |
|---|---|
| Alkylating Agents | Damages DNA |
| Antimetabolites | Interferes with DNA synthesis by mimicking metabolites needed for cancer cell reproduction |
| Antitumor antibiotics | Modifies DNA function and RNA transcription |
| Plant alkaloids | Inhibits cellular replication during metaphase of mitosis |
| Nitrosoureas | Blocks specific enzymes needed for replication |
| Corticosteroids | Disrupts cell membrane, inhibits protein synthesis, depresses immune system |
| Hormones- Cell Cycle Nonspecific | Stimulates cellular differentiation, decreases proliferation |
| Hormones- Aromatase Inhibitors | Inhibits an enzyme needed for estrogen synthesis |
| Hormones- Selective Estrogen Receptor Modulator (SERM) | Estrogen antagonist |
| Dexamethasone | Decrease inflammation and immune response (especially with Taxol) and increases appetite |
| Emend | Blocks neurokinin, the substance in the brain causing nausea & vomiting. Lasts 1 week |
| Chlorpromazine | Decreases shivering response to chemo (shivering uses energy) |
| Ativan | Relaxation, decreases CINV |
| Benadryl | Blocks histamine response to decrease allergic reaction; always given with Taxol |
Created by:
ebadger
on 2008-03-03