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Renal System O1

Clearance and transport

Define clearance Volume of plasma cleared of a substance per unit time
If substance X is filtered and completely reabsorbed, what is the clearance of X? Zero
Criteria for the clearance of a substance to be an indicator of GFR Freely filtered, not reabsorbed or secreted, not metabolized or produced
For inulin, the clearance is equal to the GFR
For PAH, the clearance is equal to the Renal plasma flow
If clearance<GFR, there has been net Reabsorption
If clearance=GFR, there has been No net reabsorption or secretion
If clearance>GFR, there has been net Secretion
Creatinine clearance is mostly _____ of urine flow Independent
As GFR decreases, creatinine clearance Decreases
Normal plasma value of creatinine 1 mg/dl
Renal urea absorption is ____ on urine flow Dependent
In volume depletion, the BUN:Cr ratio Increases
Created by: mcasto